Bi Hongmei, Ma Shenghua, Li Qingchuan, Han Xiaojun
State Key Laboratory of Urban Water Resource and Environment, School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin 150001, China.
J Mater Chem B. 2016 May 21;4(19):3269-3277. doi: 10.1039/c5tb02464a. Epub 2016 Apr 20.
This paper demonstrates that magnetic field triggered drug release from magnetic lipid microcapsules (MLMs) in a controlled manner. Two types of MLMs were fabricated, i.e., MLMs with negatively charged magnetic nanoparticles (MNPs) inside and MLMs with positively charged MNPs on their surfaces. The release of carboxyfluorescein (CF) and the chemotherapy drug doxorubicin (Dox) induced by the AC magnetic field (AMF) was investigated in detail both experimentally and theoretically. Although the drug release of these two types of MLMs synchronizes the switch of the AMF, they exhibited different mechanisms. The magnetic heating effect dominates the release of MLMs with MNPs inside, while both magnetic heating and oscillation effects play important roles in the release of MLMs with MNPs on the surfaces. The in vitro cytotoxicity experiments of Dox loaded microcapsules toward HeLa cells were further performed, which confirmed that these magnetic responsive drug carriers had obvious effects on cell death triggered by the external non-invasive AMF.
本文证明了磁场能够以可控方式触发磁性脂质微囊（MLMs）释放药物。制备了两种类型的MLMs，即内部含有带负电荷磁性纳米颗粒（MNPs）的MLMs和表面带有带正电荷MNPs的MLMs。通过实验和理论详细研究了交流磁场（AMF）诱导的羧基荧光素（CF）和化疗药物阿霉素（Dox）的释放。尽管这两种类型的MLMs的药物释放与AMF的切换同步，但它们表现出不同的机制。磁热效应主导内部含有MNPs的MLMs的释放，而磁热效应和振荡效应在表面带有MNPs的MLMs的释放中都起着重要作用。进一步进行了载有Dox的微囊对HeLa细胞的体外细胞毒性实验，证实了这些磁响应药物载体对外部非侵入性AMF触发的细胞死亡有明显影响。
