Bi Hongmei, Chen Zeqin, Qiu Jiaqin
College of Biological and Food Engineering, Guangdong University of Petrochemical Technology, Maoming, China.
College of Science, Heilongjiang Bayi Agricultural University, Daqing, China.
Des Monomers Polym. 2021 May 18;24(1):156-161. doi: 10.1080/15685551.2021.1929684.
Magnetic nanoparticles (MNPs) with safety, stability and excellent magneto-calorific effect are the precondition for the smart magnetic drug carriers' fabrication and controllable drug release at a specific target in clinical treatment. In this study, the drug release and magneto-calorific effect of two types of magnetic lipid microcapsules (MLMs) loading lipid-coated MNPs and uncoated MNPs respectively were compared deeply in experimental analysis and theoretical simulation. The simulation results revealed that almost same magnetic heat effect and temperature increasing exist between lipid-coated and uncoated MNPs, which was consistent with the experimental drug release results. Coating lipid on MNPs didn't affect the magnetic heat and heat transfer of the MNPs. Because of the heat transfer between MNPs and water, MLMs and water around, the temperature increasing of whole sample solution is lower than that of the MNPs themselves. Our results provide a reliable theoretical basis for the development of healthy, safe, and biocompatible drug delivery systems.
具有安全性、稳定性和优异磁热效应的磁性纳米颗粒是制备智能磁性药物载体并在临床治疗中实现特定靶点可控药物释放的前提条件。在本研究中，通过实验分析和理论模拟，深入比较了分别负载脂质包被磁性纳米颗粒和未包被磁性纳米颗粒的两种磁性脂质微囊（MLMs）的药物释放和磁热效应。模拟结果表明，脂质包被和未包被的磁性纳米颗粒之间存在几乎相同的磁热效应和升温情况，这与实验药物释放结果一致。在磁性纳米颗粒上包覆脂质不会影响其磁热和热传递。由于磁性纳米颗粒与周围的水、磁性脂质微囊和水之间的热传递，整个样品溶液的升温低于磁性纳米颗粒自身的升温。我们的结果为开发健康、安全且生物相容的药物递送系统提供了可靠的理论依据。
