Liu Tianyun, Li Senzhi, Liu Yuxin, Guo Quanwei, Wang Lu, Liu Dongdong, Zhou Jing
Department of Chemistry, Capital Normal University, Beijing, 100048, P. R. China.
J Mater Chem B. 2016 Apr 21;4(15):2697-2705. doi: 10.1039/c5tb02785c. Epub 2016 Apr 4.
Upconversion nanoparticles (UCNPs) have been used as building blocks in the construction of multimodal contrast agents for theranostics, that is, the combination of diagnostics and therapies. Upconversion luminescence (UCL) imaging is widely used for cell and tissue imaging while magnetic resonance imaging (MRI) is well-suited for in vivo imaging. Photothermal therapy (PTT) using (near-infrared) NIR laser radiation constitutes a minimally invasive alternative to the conventional surgical treatment of cancer. As such, multifunctional Mn-complex modified NaDyF:Yb@NaLuF:Yb,Er@polydopamine (PDA) nanocomposites (Dy@Lu@PDA-Mn) were synthesized, which was based on the fact that Yb and Er induce UCL, Dy and Mn interferes with T and T in MRI, and PDA strongly absorbs in the NIR region for PTT. Through tri-modal UCL, T-, T-weighted MRI guiding, an outstanding photothermal therapeutic efficacy with tumour elimination was obtained in a mice breast cancer model, by injection of Dy@Lu@PDA-Mn upon laser irradiation. A strategy for multimodal imaging-guided PTT was formulated and the potential of multifunctional nanostructures for use in cancer theranostics was demonstrated.
上转换纳米颗粒（UCNPs）已被用作构建用于诊疗的多模态造影剂的基础材料，即诊断与治疗相结合。上转换发光（UCL）成像广泛用于细胞和组织成像，而磁共振成像（MRI）则非常适合体内成像。使用（近红外）NIR激光辐射的光热疗法（PTT）是癌症传统手术治疗的一种微创替代方法。因此，基于Yb和Er诱导UCL、Dy和Mn干扰MRI中的T1和T2以及PDA在近红外区域对PTT有强烈吸收这一事实，合成了多功能Mn络合物修饰的NaDyF:Yb@NaLuF:Yb,Er@聚多巴胺（PDA）纳米复合材料（Dy@Lu@PDA-Mn）。通过三模态UCL、T1、T2加权MRI引导，在小鼠乳腺癌模型中，通过注射Dy@Lu@PDA-Mn并进行激光照射，获得了具有肿瘤消除效果的出色光热治疗疗效。制定了一种多模态成像引导PTT的策略，并证明了多功能纳米结构在癌症诊疗中的应用潜力。
