基于锆簇的金属有机框架材料中的压力控制药物释放
Pressure controlled drug release in a Zr-cluster-based MOF.
作者信息
Jiang Ke, Zhang Ling, Hu Quan, Zhao Dian, Xia Tifeng, Lin Wenxin, Yang Yanyu, Cui Yuanjing, Yang Yu, Qian Guodong
机构信息
State Key Laboratory of Silicon Materials, Cyrus Tang Center for Sensor Materials and Applications, School of Materials Science & Engineering, Zhejiang University, Hangzhou 310027, China.
出版信息
J Mater Chem B. 2016 Oct 21;4(39):6398-6401. doi: 10.1039/c6tb01756h. Epub 2016 Sep 16.
A robust zirconium-cluster-based metal-organic framework (MOF) ZJU-800 with an excellent drug loading capacity (about 58.80 wt%) has been synthesized. The system shows an adjustable release time of the drug diclofenac sodium from 2 days to 8 days by controlling the degree of compaction between MOF and drug using pressure.
已合成出一种具有出色载药能力（约58.80 wt%）的基于锆簇的坚固金属有机框架（MOF）ZJU-800。通过使用压力控制MOF与药物之间的压实程度，该体系显示出双氯芬酸钠药物的释放时间可在2天至8天之间调节。
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