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功能化金属有机框架纳米颗粒作为癌症治疗靶向给药系统的应用。

Utilization of Functionalized Metal-Organic Framework Nanoparticle as Targeted Drug Delivery System for Cancer Therapy.

作者信息

Tran Vy Anh, Thuan Le Van, Doan Van Dat, Vo Giang N L

机构信息

Institute of Applied Technology and Sustainable Development, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam.

Faculty of Environmental and Food Engineering, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam.

出版信息

Pharmaceutics. 2023 Mar 13;15(3):931. doi: 10.3390/pharmaceutics15030931.

DOI:10.3390/pharmaceutics15030931
PMID:36986793
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10051794/
Abstract

Cancer is a multifaceted disease that results from the complex interaction between genetic and environmental factors. Cancer is a mortal disease with the biggest clinical, societal, and economic burden. Research on better methods of the detection, diagnosis, and treatment of cancer is crucial. Recent advancements in material science have led to the development of metal-organic frameworks, also known as MOFs. MOFs have recently been established as promising and adaptable delivery platforms and target vehicles for cancer therapy. These MOFs have been constructed in a fashion that offers them the capability of drug release that is stimuli-responsive. This feature has the potential to be exploited for cancer therapy that is externally led. This review presents an in-depth summary of the research that has been conducted to date in the field of MOF-based nanoplatforms for cancer therapeutics.

摘要

癌症是一种多方面的疾病，由遗传和环境因素之间的复杂相互作用引起。癌症是一种致命疾病，带来最大的临床、社会和经济负担。研究更好的癌症检测、诊断和治疗方法至关重要。材料科学的最新进展导致了金属有机框架（也称为MOF）的发展。MOF最近已被确立为有前景且适应性强的癌症治疗递送平台和靶向载体。这些MOF的构建方式使其具有刺激响应性药物释放能力。这一特性有可能被用于外部引导的癌症治疗。本综述深入总结了迄今为止在基于MOF的癌症治疗纳米平台领域所开展的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/42c20ba81fbf/pharmaceutics-15-00931-g014.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/8a69d52dad99/pharmaceutics-15-00931-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/3bfd2913c838/pharmaceutics-15-00931-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/e1d114f48d43/pharmaceutics-15-00931-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/2f051613e870/pharmaceutics-15-00931-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/1b0da742e43a/pharmaceutics-15-00931-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/59f97d07c63f/pharmaceutics-15-00931-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/4dfec451c7eb/pharmaceutics-15-00931-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/42c20ba81fbf/pharmaceutics-15-00931-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/6b7ffa151e34/pharmaceutics-15-00931-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/25c8a4585f95/pharmaceutics-15-00931-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/4a835128afd7/pharmaceutics-15-00931-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/717f4cf9412c/pharmaceutics-15-00931-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/035dc6dccbec/pharmaceutics-15-00931-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/8abe1f1628ec/pharmaceutics-15-00931-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/8a69d52dad99/pharmaceutics-15-00931-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/3bfd2913c838/pharmaceutics-15-00931-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/e1d114f48d43/pharmaceutics-15-00931-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/2f051613e870/pharmaceutics-15-00931-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/1b0da742e43a/pharmaceutics-15-00931-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/59f97d07c63f/pharmaceutics-15-00931-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/4dfec451c7eb/pharmaceutics-15-00931-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6159/10051794/42c20ba81fbf/pharmaceutics-15-00931-g014.jpg

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