Wang Shuailiang, Bi Anyao, Zeng Wenbin, Cheng Zhen
School of Pharmaceutical Sciences, Central South University, 172 Tongzipo Road, Changsha, 410013, P. R. China.
J Mater Chem B. 2016 Aug 28;4(32):5331-5348. doi: 10.1039/c6tb00709k. Epub 2016 Jul 14.
Lanthanide ion doped upconversion nanoparticles (UCNPs) are known to be able to convert long-wavelength excitation light (usually 980 nm) into high-energy ultraviolet (UV) or visible emissions, and they have attracted significant attention because of their distinct photochemical properties including sharp emission bands, low autofluorescence, high tissue penetration depth, inertness to ambient interference and minimal photodamage to tissues. Until now, UCNPs have shown great potential in various realms including bioimaging, biosensing and biomedical applications. Especially in recent years, UCNP based nanocomposites have been found to be promising tools for multi-modal imaging and low-invasive photo-based therapy of tumors. In this review, we summarize the recent achievement and progress of UCNP based multifunctional nanoplatforms for bioimaging and cancer phototheranostics, including photodynamic therapy (PDT) and photothermal therapy (PTT). Furthermore, some emerging trends, future directions as well as challenges in this rapidly growing field are discussed.
已知镧系离子掺杂的上转换纳米颗粒（UCNPs）能够将长波长激发光（通常为980nm）转换为高能紫外线（UV）或可见光发射，并且由于其独特的光化学性质，包括尖锐的发射带、低自发荧光、高组织穿透深度、对环境干扰的惰性以及对组织的最小光损伤，它们已引起了广泛关注。到目前为止，UCNPs在包括生物成像、生物传感和生物医学应用在内的各个领域都显示出了巨大的潜力。特别是近年来，基于UCNP的纳米复合材料已被发现是用于肿瘤多模态成像和低侵入性光基治疗的有前途的工具。在这篇综述中，我们总结了基于UCNP的多功能纳米平台在生物成像和癌症光诊疗方面的最新成果和进展，包括光动力疗法（PDT）和光热疗法（PTT）。此外，还讨论了这个快速发展领域中的一些新兴趋势、未来方向以及挑战。
