用于细胞成像的双功能荧光修饰人血清白蛋白钴铁氧体磁性纳米颗粒
Difunctional fluorescent HSA modified CoFeO magnetic nanoparticles for cell imaging.
作者信息
Yao Qianfang, Zheng Yang, Cheng Wenyu, Chen MengJun, Shen Jie, Yin Meizhen
机构信息
State Key Laboratory of Chemical Resource Engineering, Key Laboratory of Carbon Fiber and Functional Polymers of Ministry of Education, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, 100029 Beijing, China.
出版信息
J Mater Chem B. 2016 Oct 14;4(38):6344-6349. doi: 10.1039/c6tb01787h. Epub 2016 Sep 19.
Difunctional fluorescent CoFeO magnetic nanoparticles were prepared through a facile method. After the absorption of dopamine, human serum albumin (HSA) was easily attached onto the surface of CoFeO magnetic nanoparticles through a reversible non-covalent bond between HSA and -NH in dopamine. With the same type of interaction, the designed perylene diimide (PDI) based -NH rich fluorescent molecule (PDI-4NH) was decorated on the HSA-modified CoFeO nanoparticles. The produced fluorescent magnetic nanoparticles exhibited great biocompatibility and could successfully enter the cell. Therefore, we have developed a novel method to obtain fluorescent magnetic nanoparticles with potential biomedical applications.
通过一种简便的方法制备了双功能荧光CoFeO磁性纳米粒子。在多巴胺吸附后，人血清白蛋白（HSA）通过HSA与多巴胺中-NH之间的可逆非共价键轻松附着在CoFeO磁性纳米粒子表面。通过相同类型的相互作用，将设计的基于苝二酰亚胺（PDI）的富含-NH的荧光分子（PDI-4NH）修饰在HSA修饰的CoFeO纳米粒子上。所制备的荧光磁性纳米粒子表现出良好的生物相容性，并能成功进入细胞。因此，我们开发了一种获得具有潜在生物医学应用的荧光磁性纳米粒子的新方法。
Zotero 插件