Yamakawa M, Maeda J, Mimura Y, Fujita T, Sugisaki K, Furuya K, Oohara T
Third Department of Surgery, Faculty of Medicine, Tokyo University, Japan.
Nihon Geka Gakkai Zasshi. 1988 Sep;89(9):1355-8.
Energy metabolism of fat emulsion was studied in rats with septic condition. The results indicate that fat emulsion was rapidly eliminated from the blood stream and metabolized readily even in such condition. Based on these findings, we have actively employed fat emulsion clinically as an energy source of septic patients. In septic rats, it was demonstrated that levels of carnitine decreased and that this decrease was based upon a decrease of synthesis. When carnitine was administered together with fat emulsion, the energy metabolism returned to approximately normal level. This reports also describes the absorption and utilization of orally administered fat in septic rats.
研究了脓毒症大鼠脂肪乳剂的能量代谢。结果表明，即使在这种情况下，脂肪乳剂也能迅速从血流中清除并易于代谢。基于这些发现，我们在临床上积极将脂肪乳剂用作脓毒症患者的能量来源。在脓毒症大鼠中，已证明肉碱水平降低，且这种降低是基于合成减少。当肉碱与脂肪乳剂一起给药时，能量代谢恢复到大致正常水平。本报告还描述了脓毒症大鼠口服脂肪的吸收和利用情况。
