Chen W J
JPEN J Parenter Enteral Nutr. 1984 Jan-Feb;8(1):14-7. doi: 10.1177/014860718400800114.
Utilization of exogenous fat emulsion (Intralipid) in control, early septic, and late septic rats were studied. After intravenous infusion of 14C-Intralipid, cumulative amounts of 14CO2 in the expired breath in the 6-hr period were 42.8 +/- 1.8, 35.0 +/- 1.8, and 28.5 +/- 1.6% of the injected dose, respectively, for the three groups. The amount and the maximum rate of CO2 production correlated with the severity of sepsis. Significantly greater amounts of plasma triglyceride and free fatty acids were also observed in septic rats. The hyperlipemia associated with the observed decrease in plasma clearance of lipids may account for the decreased utilization of exogenous fat in septic rats.
研究了外源性脂肪乳剂（英脱利匹特）在对照大鼠、早期脓毒症大鼠和晚期脓毒症大鼠中的利用情况。静脉输注14C-英脱利匹特后，三组大鼠在6小时内呼出气体中14CO2的累积量分别为注射剂量的42.8±1.8%、35.0±1.8%和28.5±1.6%。二氧化碳产生量和最大产生速率与脓毒症的严重程度相关。在脓毒症大鼠中还观察到血浆甘油三酯和游离脂肪酸的量显著增加。与观察到的血浆脂质清除率降低相关的高脂血症可能是脓毒症大鼠中外源性脂肪利用减少的原因。
