Carril Monica
CIC biomaGUNE, Paseo Miramón 182, 20014 Donostia, San Sebastian, Spain.
J Mater Chem B. 2017 Jun 21;5(23):4332-4347. doi: 10.1039/c7tb00093f. Epub 2017 Feb 28.
Magnetic resonance imaging (MRI) is a non-invasive imaging technique with widespread use in diagnosis. Frequently, contrast in MRI is enhanced with the aid of a contrast agent, among which smart, responsive, OFF/ON or activatable probes are of particular interest. These kinds of probes elicit a response to selective stimuli, evidencing the presence of enzymes or acidic pH, for instance. In this review, we will focus on smart probes that are detectable by both H and F MRI, frequently based on nanomaterials. We will discuss the triggering factors and the strategies employed thus far to activate each probe.
磁共振成像（MRI）是一种非侵入性成像技术，在诊断中广泛应用。通常，MRI中的对比度借助造影剂增强，其中智能、响应性、关闭/开启或可激活探针尤其受关注。这类探针会对选择性刺激产生反应，例如证明酶或酸性pH的存在。在本综述中，我们将聚焦于可通过氢和氟MRI检测的智能探针，这类探针通常基于纳米材料。我们将讨论触发因素以及迄今为止用于激活每种探针的策略。
