Yang Chunjie, Wang Qian, Ding Wu
College of Health Science, Yuncheng Polytechnic College Yuncheng Shanxi 044000 PR China.
College of Food Science and Engineering, Northwest A&F University Yangling Shaanxi 712100 PR China
RSC Adv. 2019 Aug 13;9(44):25285-25302. doi: 10.1039/c9ra04508b.
Enzymatic activities are important for normal physiological processes and are also critical regulatory mechanisms for many pathologies. Identifying the enzyme activities has considerable importance in disease diagnoses and monitoring of the physiological metabolism. In the past few years, great strides have been made towards the imaging detection of enzyme activity based on optical modality, MRI modality, nuclear modality, photoacoustic modality and multifunctional modality. This review summarizes the latest advances in the imaging detection of enzyme activities reported within the past years, mainly concentrating on the probe design, imaging strategies and demonstration of enzyme activities . This review also highlights the potential challenges and the further directions of this field.
酶活性对于正常生理过程至关重要，也是许多病理状态的关键调节机制。识别酶活性在疾病诊断和生理代谢监测中具有相当重要的意义。在过去几年中，基于光学模态、磁共振成像（MRI）模态、核模态、光声模态和多功能模态，在酶活性的成像检测方面取得了长足进展。本综述总结了过去几年报道的酶活性成像检测的最新进展，主要集中在探针设计、成像策略和酶活性的论证方面。本综述还强调了该领域的潜在挑战和未来发展方向。
