用于增强 T 加权磁共振成像应用的两性离子包覆超小氧化铁纳米颗粒。
Zwitterion-coated ultrasmall iron oxide nanoparticles for enhanced T-weighted magnetic resonance imaging applications.
作者信息
Ma Dan, Chen Jingwen, Luo Yu, Wang Han, Shi Xiangyang
机构信息
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China.
出版信息
J Mater Chem B. 2017 Sep 21;5(35):7267-7273. doi: 10.1039/c7tb01588g. Epub 2017 Aug 24.
We report a convenient strategy to prepare ultrasmall FeO nanoparticles (NPs) coated with zwitterion l-cysteine (Cys) for enhanced T-weighted magnetic resonance (MR) imaging applications. The formed FeO-PEG-Cys NPs possess antifouling properties, good r relaxivity, excellent cytocompatibility and hemocompatibility, and can be used as a contrast agent for enhanced blood pool and tumor MR imaging.
我们报道了一种简便的策略，用于制备包覆两性离子 l-半胱氨酸（Cys）的超小 FeO 纳米颗粒（NPs），以用于增强 T 加权磁共振（MR）成像应用。所形成的 FeO-PEG-Cys NPs 具有抗污性能、良好的 r 弛豫率、优异的细胞相容性和血液相容性，并且可用作增强血池和肿瘤 MR 成像的造影剂。
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