Li Liping, Zhang Ruiping, Lu Chunxiang, Sun Jinghua, Wang Lingjie, Qu Botao, Li Tingting, Liu Yaodong, Li Sijin
National Engineering Laboratory for Carbon Fiber Technology, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan 030001, P. R. China.
J Mater Chem B. 2017 Sep 21;5(35):7328-7334. doi: 10.1039/c7tb00634a. Epub 2017 Aug 23.
Near infrared (NIR)-light emitting fluorescent probes have attracted extensive research attention in the bioimaging field due to their deep tissue penetration, minimal auto-fluorescence and lower emission light damage to bio-tissues. Herein, we designed and prepared NIR-light emitting CDs (R-CDs) from spinach by a one-step solvothermal method. The R-CDs exhibited good water solubility, a maximum fluorescence emission peak at 680 nm, a high quantum yield of 15.34%, remarkable photo-stability and resistance to metal ions in a body-simulating environment, excellent compatibility, negligible toxicity, and superior labelling capability in vitro and in vivo. These findings significantly highlight the design of NIR-light emitting CDs and exploit their bio-imaging applications.
近红外（NIR）发光荧光探针因其在深层组织中的穿透性、最小的自发荧光以及对生物组织的较低发射光损伤，在生物成像领域引起了广泛的研究关注。在此，我们通过一步溶剂热法从菠菜中设计并制备了近红外发光碳点（R-CDs）。R-CDs表现出良好的水溶性、在680nm处的最大荧光发射峰、15.34%的高量子产率、在人体模拟环境中显著的光稳定性和对金属离子的抗性、优异的兼容性、可忽略不计的毒性以及在体外和体内的卓越标记能力。这些发现显著突出了近红外发光碳点的设计并开拓了它们的生物成像应用。
