Fang Lin, Wang Weiqi, Liu Yang, Xie Zhigang, Chen Li
Department of Chemistry, Northeast Normal University, 5268 Remin Street, Changchun, 130024, P. R. China.
J Mater Chem B. 2017 Nov 28;5(44):8833-8838. doi: 10.1039/c7tb02144e. Epub 2017 Nov 1.
It is challenging to develop a chemo-photothermal combination therapy using Au-based nanostructures. Au nanorods (AuNRs) provide an attractive method for treating solid tumors in a minimally invasive manner because of their capability of converting the absorbed radiation into heat energy. Although anisotropic AuNRs possess an excellent photothermal effect, the addition of other therapeutic agents is still needed for enhanced antitumor efficiency. With the aim of finding a combination therapy, in the present study, mesoporous silica (mSiO) was employed to partly coat AuNRs to build a Janus AuNRs@mSiO as a chemo-photothermal platform. The experimental results indicate that the mSiO shell apparently reduces the cytotoxicity of AuNRs. In addition, the coated mSiO can load doxorubicin (DOX) for chemotherapy, resulting in the improved chemo-photothermal therapy of Janus AuNRs@mSiO-DOX compared with the single photothermal therapy of AuNRs. This work provides an alternative approach for establishing a multifunctional platform based on Au nanostructures for biomedical applications.
利用金基纳米结构开发化学-光热联合疗法具有挑战性。金纳米棒（AuNRs）因其能够将吸收的辐射转化为热能，为以微创方式治疗实体瘤提供了一种有吸引力的方法。尽管各向异性的金纳米棒具有优异的光热效应，但仍需要添加其他治疗剂以提高抗肿瘤效率。为了找到一种联合疗法，在本研究中，采用介孔二氧化硅（mSiO）对金纳米棒进行部分包覆，构建了一种Janus金纳米棒@mSiO作为化学-光热平台。实验结果表明，mSiO壳层明显降低了金纳米棒的细胞毒性。此外，包覆的mSiO可以负载阿霉素（DOX）用于化疗，与金纳米棒的单一光热疗法相比，Janus金纳米棒@mSiO-DOX的化学-光热联合疗法得到了改善。这项工作为基于金纳米结构建立用于生物医学应用的多功能平台提供了一种替代方法。
