多功能 PB@mSiO2-PEG/DOX 纳米平台用于肿瘤的光热-化学联合治疗。
A Multifunctional PB@mSiO2-PEG/DOX Nanoplatform for Combined Photothermal-Chemotherapy of Tumor.
机构信息
Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
Department of Hepatopancreatobiliary Surgery, Drum Tower Hospital, Medical School of Nanjing University , Nanjing 210008, People's Republic of China.
出版信息
ACS Appl Mater Interfaces. 2016 Jul 13;8(27):17038-46. doi: 10.1021/acsami.6b01147. Epub 2016 Jun 28.
In this work, we design mesoporous silica-coated Prussian blue nanocubes with PEGyltation to construct multifunctional PB@mSiO2-PEG nanocubes. The PB@mSiO2-PEG nanocubes have good biocompatibility, excellent photothermal transformation capacity, in vivo magnetic resonance and photoacoustic imaging ability. After loading antitumor drug doxorubicin (DOX) in the PB@mSiO2-PEG nanocubes, the constructured PB@mSiO2-PEG/DOX nanoplatforms show an excellent pH-responsive drug release character within 48 h, namely, an ultralow cumulative drug release amount of 3.1% at pH 7.4 and a high release amount of 46.6% at pH 5.0. Upon near-infrared laser irradiation, the PB@mSiO2-PEG/DOX nanoplatforms show an enhanced synergistic photothermal and chemical therapeutic efficacy for breast cancer than solo photothermal therapy or chemotherapy.
在这项工作中，我们设计了具有聚乙二醇化的介孔硅包覆普鲁士蓝纳米立方体制备多功能 PB@mSiO2-PEG 纳米立方。PB@mSiO2-PEG 纳米立方具有良好的生物相容性、优异的光热转换能力、体内磁共振和光声成像能力。在 PB@mSiO2-PEG 纳米立方中装载抗肿瘤药物阿霉素（DOX）后，构建的 PB@mSiO2-PEG/DOX 纳米平台在 48 小时内表现出优异的 pH 响应性药物释放特性，即在 pH 7.4 时的累积药物释放量低至 3.1%，而在 pH 5.0 时的释放量高达 46.6%。近红外激光照射后，PB@mSiO2-PEG/DOX 纳米平台对乳腺癌的光热和化学协同治疗效果优于单纯光热治疗或化学治疗。
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