Jang Hongje, Kang Kyungtae, El-Sayed Mostafa A
Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.
J Mater Chem B. 2017 Aug 14;5(30):6147-6153. doi: 10.1039/c7tb01123g. Epub 2017 Jul 24.
To conquer cancer, one of the most dangerous and common diseases faced by humanity, many therapeutic approaches have been researched and developed. Discovery of highly effective therapeutic molecules without side effects and novel strategies for their effective delivery are areas receiving recent global interest. Here, we describe a facile one-pot synthetic method for making gold nanoparticles coated with fucoidan, a natural product extracted from brown seaweed and a promising anticancer biopolymer. This nanoparticle formulation with well-controlled size distribution shows promise in enhancing the therapeutic and delivery efficacy. Moreover, stable surface modification of fucoidan coating followed by conjugation of doxorubicin through cleavable linkage significantly improved the anticancer effect. Fucoidan-coated gold nanoparticles containing doxorubicin exhibited more greatly enhanced anticancer effect than any other related platform following fucoidan-based cancer treatment adopting the nanoparticle integrated system.
为攻克癌症这一人类面临的最危险且常见的疾病之一，人们研究并开发了许多治疗方法。发现无副作用的高效治疗分子及其有效递送的新策略是近期全球关注的领域。在此，我们描述了一种简便的一锅合成法，用于制备包覆有岩藻依聚糖的金纳米颗粒，岩藻依聚糖是一种从褐藻中提取的天然产物，也是一种很有前景的抗癌生物聚合物。这种尺寸分布可控的纳米颗粒制剂在提高治疗和递送效果方面显示出前景。此外，岩藻依聚糖涂层的稳定表面修饰以及随后通过可裂解连接体偶联阿霉素显著提高了抗癌效果。在采用纳米颗粒集成系统进行基于岩藻依聚糖的癌症治疗后，含有阿霉素的岩藻依聚糖包覆金纳米颗粒表现出比任何其他相关平台更显著增强的抗癌效果。
