Wang Li, Zhang Hongwei, Zhou Zhiguo, Kong Bin, An Lu, Wei Jie, Yang Hong, Zhao Jiangmin, Yang Shiping
The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China.
J Mater Chem B. 2015 Feb 21;3(7):1433-1438. doi: 10.1039/c4tb01981d. Epub 2015 Jan 13.
In this work, ultra-small iron oxide nanoparticles were synthesized using high temperature pyrolysis. For further functionalization, dopamine was anchored onto the surface of ultra-small iron oxide nanoparticles (FeO@DOPA NPs). Gd(iii) ions were chelated with diethylenetriaminepentaacetic acid (DTPA) which was linked with dopamine. The resulting Gd(iii) complex conjugated ultra-small FeO NPs [FeO@DOPA(Gd-DTPA) NPs] were characterized by XRD pattern and TEM. The longitudinal relaxivity (r) of FeO@DOPA(Gd-DTPA) NPs was 9.97 mM S. Compared to ultra-small FeO NPs and Gd(iii) complexes, FeO@DOPA(Gd-DTPA) NPs showed a significant improvement of the T-weighted MR image in aqueous solution, in vitro and in vivo.
在本研究中，采用高温热解法合成了超小氧化铁纳米颗粒。为了进一步功能化，将多巴胺锚定在超小氧化铁纳米颗粒（FeO@DOPA NPs）表面。钆（III）离子与与多巴胺相连的二乙烯三胺五乙酸（DTPA）螯合。通过X射线衍射图谱和透射电子显微镜对所得的钆（III）配合物共轭超小FeO纳米颗粒[FeO@DOPA(Gd-DTPA) NPs]进行了表征。FeO@DOPA(Gd-DTPA) NPs的纵向弛豫率（r）为9.97 mM s。与超小FeO纳米颗粒和钆（III）配合物相比，FeO@DOPA(Gd-DTPA) NPs在水溶液、体外和体内的T加权磁共振图像上均有显著改善。
