Wang Kaili, An Lu, Tian Qiwei, Lin Jiaomin, Yang Shiping
The Key Laboratory of Resource Chemistry of the Ministry of Education, The Shanghai Key Laboratory of Rare Earth Functional Materials, The Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University Shanghai 200234 China
RSC Adv. 2018 Jul 26;8(47):26764-26770. doi: 10.1039/c8ra04530e. eCollection 2018 Jul 24.
Magnetic resonance imaging (MRI) is indispensable and powerful in modern clinical diagnosis and has some advantages such as non-invasiveness and high penetration depth. Furthermore, dual - MR imaging has attracted crucial interest as it can decrease the risk of pseudo-positive signals in diagnosing lesions. And it's worth nothing that the dual-mode MR imaging displays a vital platform to provide relatively comprehensive diagnosis information and receive accurate results. Herein, we report a dual - MR imaging contrast agent (CA) grounded on the iron/iron oxide core/shell nanomaterials conjugated with gadolinium chelate. The Gd-labeled Fe@FeO NPs reveal the feasibility to utilize them to serve as a dual - MR imaging CA, and the relaxivity results in a 0.5 T MR system showed a longitudinal relaxivity value ( ) and transverse relaxivity value ( ) of 7.2 mM s and 109.4 mM s, respectively. The MTT results demonstrate the Gd-labeled Fe@FeO NPs have no obvious cytotoxicity and a good compatibility. The and MRI generated a brighter effect and darkening in -weighted MR imaging and -weighted images, respectively. The results clearly indicate that Gd-labeled Fe@FeO NPs have potential as a magnetic resonance imaging contrast reagent.
磁共振成像（MRI）在现代临床诊断中不可或缺且功能强大，具有非侵入性和高穿透深度等优点。此外，双模态磁共振成像引起了广泛关注，因为它可以降低病变诊断中假阳性信号的风险。值得注意的是，双模态磁共振成像提供了一个重要平台，可提供相对全面的诊断信息并获得准确结果。在此，我们报道了一种基于与钆螯合物共轭的铁/氧化铁核/壳纳米材料的双模态磁共振成像造影剂（CA）。钆标记的Fe@FeO NPs显示出将它们用作双模态磁共振成像CA的可行性，在0.5 T磁共振系统中的弛豫率结果显示纵向弛豫率值（ ）和横向弛豫率值（ ）分别为7.2 mM s和109.4 mM s。MTT结果表明钆标记的Fe@FeO NPs没有明显的细胞毒性且具有良好的兼容性。 和 磁共振成像分别在加权磁共振成像和加权图像中产生了更亮的效果和变暗。结果清楚地表明钆标记的Fe@FeO NPs有潜力作为磁共振成像造影剂。
