Chen Jing, Xiang Hui-Hui, Zhao Zu-Zhi, Wu Yun-Kai, Fei Meng-Yu, Song Meng-Meng
School of Basic Medical Sciences, Anhui Medical University 81 Meishan Road 230032 Hefei Anhui PR China
Department of CT/MRI, Anhui No. 2 Provincial People's Hospital 1868 Dangshan Road, North Second Ring Road 230032 Hefei Anhui PR China.
RSC Adv. 2020 May 12;10(31):18054-18061. doi: 10.1039/d0ra01807d. eCollection 2020 May 10.
An ultra-sensitive -weighted MR imaging contrast agent was prepared based on FeO nanoparticles and Gd ions (FeO@Gd). Amino modified FeO nanoparticles were conjugated to diethylenetriamine pentaacetic acid, and finally coordinated with Gd ions. The nanoparticles had a uniform morphology with a size of 100 nm and a Gd/Fe mass ratio of 1/110. The (transverse relaxivity) of the FeO nanoparticles increased from 131.89 mM s to 202.06 mM s after coordination with Gd ions. MR measurements showed that the aqueous dispersion of FeO@Gd nanoparticles had an obvious concentration-dependent negative contrast enhancement. Hepatoma cells were selected to test the cytotoxicity and MR imaging effect. The application of FeO@Gd nanoparticles as contrast agents was also exploited for -weighted MR imaging of rat livers. All the results showed the effectiveness of the nanoparticles in MR diagnosis.
基于FeO纳米颗粒和Gd离子制备了一种超灵敏的加权磁共振成像造影剂（FeO@Gd）。氨基修饰的FeO纳米颗粒与二乙烯三胺五乙酸共轭，最终与Gd离子配位。纳米颗粒形态均匀，尺寸为100 nm，Gd/Fe质量比为1/110。与Gd离子配位后，FeO纳米颗粒的横向弛豫率从131.89 mM⁻¹s⁻¹增加到202.06 mM⁻¹s⁻¹。磁共振测量表明，FeO@Gd纳米颗粒的水分散体具有明显的浓度依赖性负性对比增强。选择肝癌细胞来测试细胞毒性和磁共振成像效果。FeO@Gd纳米颗粒作为造影剂的应用也被用于大鼠肝脏的加权磁共振成像。所有结果均表明纳米颗粒在磁共振诊断中的有效性。
