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一种基于核壳金属有机框架（MOF）的智能纳米复合材料，用于对缺氧肿瘤细胞进行高效的近红外/过氧化氢响应性光动力治疗。

A core-shell metal-organic-framework (MOF)-based smart nanocomposite for efficient NIR/HO-responsive photodynamic therapy against hypoxic tumor cells.

作者信息

Cai Hui-Juan, Shen Ting-Ting, Zhang Jian, Shan Chang-Fu, Jia Jian-Guo, Li Xiang, Liu Wei-Sheng, Tang Yu

机构信息

State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.

出版信息

J Mater Chem B. 2017 Apr 7;5(13):2390-2394. doi: 10.1039/c7tb00314e. Epub 2017 Mar 20.

DOI:10.1039/c7tb00314e
PMID:32264545
Abstract

Core-shell MOF-based smart nanocomposite UCNPs/MB@ZIF-8@catalase (UCNPs = upconversion nanoparticles; MB = methylene blue; ZIF = zeolitic imidazolate framework) has been constructed for bio-imaging and efficient NIR/HO-responsive photodynamic therapy against hypoxic tumor cells. The nanoporous MOF shell can prevent aggregation of photosensitizers and serve as an efficient self-sufficient oxygen gas acceptor.

摘要

基于核壳型金属有机框架的智能纳米复合材料上转换纳米颗粒/亚甲蓝@沸石咪唑酯骨架-8@过氧化氢酶（UCNPs = 上转换纳米颗粒；MB = 亚甲蓝；ZIF = 沸石咪唑酯骨架）已被构建用于生物成像以及针对缺氧肿瘤细胞的高效近红外/过氧化氢响应性光动力疗法。纳米多孔金属有机框架外壳可以防止光敏剂聚集，并作为一种高效的自给自足的氧气受体。

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