Ang Chen, Zhang Jia, Chu Mingyuan, Li Hehui, Tian Mengyu, Feng Xiaoxia, Zhang Manli, Liu Li, Meng Xiangzhi, Ding Guosheng
State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
School of Psychology, University of Aberdeen, Aberdeen, United Kingdom.
Front Psychol. 2020 Mar 20;11:420. doi: 10.3389/fpsyg.2020.00420. eCollection 2020.
The engagement of the cerebellum VI in reading was reported in both typically developing and dyslexic readers. However, it is still not clear how the cerebellum VI contributes to reading. Here we have examined the correlation of intrinsic cerebro-cerebellar functional connectivity with two critical reading-related skills-phonological awareness (PA) and rapid automatized naming (RAN)-with fMRI technology. Specifically, we tested the hypothesis that the cerebellum may contribute to reading either by phonological skills or by automatizing skills. We chose the left and right cerebellum VI as ROIs, and we calculated the intrinsic cerebro-cerebellar functional connectivity during a resting state. We further explored whether and how cerebro-cerebellar resting state functional connectivity (RSFC) is associated with individuals' reading-related skills including PA and RAN. The results showed that the functional connectivity between the left supramarginal gyrus and bilateral cerebellum VI was related to RAN, and the connectivity between the left insula and right cerebellum VI was related to PA. However, the effect of PA did not survive after the RAN was regressed out. Control analyses further confirmed that it was the intrinsic cerebro-cerebellar functional connectivity rather than the local cerebellar functionality that associated with phonological awareness ability and rapid automatized naming ability. For the first time, the relationship between cerebro-cerebellar resting state functional connectivity and specific reading-related skills has been explored, and this has deepened our understanding of the way the cerebellum VI is involved in reading.
在正常发育的读者和阅读障碍读者中均有报道小脑VI区参与阅读。然而，小脑VI区如何促进阅读仍不清楚。在此，我们使用功能磁共振成像技术研究了脑-小脑内在功能连接与两项关键的阅读相关技能——语音意识（PA）和快速自动命名（RAN）之间的相关性。具体而言，我们检验了小脑可能通过语音技能或技能自动化来促进阅读的假设。我们选择左右小脑VI区作为感兴趣区（ROI），并计算静息状态下的脑-小脑内在功能连接。我们进一步探讨了脑-小脑静息状态功能连接（RSFC）是否以及如何与个体的阅读相关技能（包括PA和RAN）相关。结果表明，左侧缘上回与双侧小脑VI区之间的功能连接与RAN相关，左侧脑岛与右侧小脑VI区之间的连接与PA相关。然而，在排除RAN的影响后，PA的效应不再显著。对照分析进一步证实，与语音意识能力和快速自动命名能力相关的是脑-小脑内在功能连接，而非局部小脑功能。首次探索了脑-小脑静息状态功能连接与特定阅读相关技能之间的关系，这加深了我们对小脑VI区参与阅读方式的理解。
