BCL11A促进喉鳞状细胞癌的进展。

BCL11A Promotes the Progression of Laryngeal Squamous Cell Carcinoma.

作者信息

Zhou Jian, Zhou Liang, Zhang Duo, Tang Wei-Jing, Tang Di, Shi Xiao-Ling, Yang Yue, Zhou Lin, Liu Fei, Yu Yong, Liu Pentao, Tao Lei, Lu Li-Ming

机构信息

Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China.

出版信息

Front Oncol. 2020 Mar 20;10:375. doi: 10.3389/fonc.2020.00375. eCollection 2020.

We report functional and clinical data uncovering the significance of B-cell lymphoma/leukemia 11A (BCL11A) in laryngeal squamous cell carcinoma (LSCC). We examined BCL11A expression in a cohort of LSCC patients and evaluated the association between BCL11A expression and clinicopathological features. We investigated the consequences of overexpressing BCL11A in the LSCC cell line on proliferation, migration, invasion, cell cycle, chemosensitivity, and growth . We explored the relationship between BCL11A and MDM2 in LSCC and tumorigenesis pathways by using the Human Cancer PathwayFinder Array. High levels of BCL11A were found in LSCC tissues and were more frequently associated with advanced lymphatic metastasis stages with poor prognoses. BCL11A overexpression enhanced LSCC proliferation and . A positive correlation between MDM2 and BCL11A expression was identified. These data uncover important functions of BCL11A in LSCC and identify BCL11A as a prognostic biomarker and potential therapeutic target in LSCC.

我们报告了功能和临床数据，揭示了B细胞淋巴瘤/白血病11A（BCL11A）在喉鳞状细胞癌（LSCC）中的重要性。我们检测了一组LSCC患者中BCL11A的表达，并评估了BCL11A表达与临床病理特征之间的关联。我们研究了在LSCC细胞系中过表达BCL11A对增殖、迁移、侵袭、细胞周期、化疗敏感性和生长的影响。我们使用人类癌症通路检测阵列探索了LSCC中BCL11A与MDM2之间的关系以及肿瘤发生途径。在LSCC组织中发现高水平的BCL11A，且其更常与预后不良的晚期淋巴转移阶段相关。BCL11A过表达增强了LSCC的增殖。MDM2与BCL11A表达之间存在正相关。这些数据揭示了BCL11A在LSCC中的重要功能，并将BCL11A确定为LSCC的预后生物标志物和潜在治疗靶点。