Lebeau Juliana, Efromson John P, Lynch Michael D
Department of Biomedical Engineering, Duke University, Durham, NC, United States.
Front Bioeng Biotechnol. 2020 Mar 20;8:207. doi: 10.3389/fbioe.2020.00207. eCollection 2020.
Industrial biotechnology can lead to new routes and potentially to more sustainable production of numerous chemicals. We review the potential of biobased routes from sugars to the large volume commodity, methacrylic acid, involving fermentation based bioprocesses. We cover the key progress over the past decade on direct and indirect fermentation based routes to methacrylic acid including both academic as well as patent literature. Finally, we take a critical look at the potential of biobased routes to methacrylic acid in comparison with both incumbent as well as newer greener petrochemical based processes.
工业生物技术能够带来新的途径，并有可能实现多种化学品更可持续的生产。我们综述了从糖类出发，通过基于发酵的生物过程生产大量大宗商品甲基丙烯酸的生物基途径的潜力。我们涵盖了过去十年中在基于直接和间接发酵的甲基丙烯酸生产途径方面取得的关键进展，包括学术文献和专利文献。最后，我们批判性地审视了生物基甲基丙烯酸生产途径与现有以及更新的绿色石化生产工艺相比的潜力。
