Long noncoding RNA promotes head and neck squamous cell carcinoma cell epithelial-mesenchymal transition by targeting .

To explore the biological functions and clinicopathologic significance of the long noncoding RNA in head and neck squamous cell carcinoma (HNSCC). We assessed the effects of and identified the target miRNA by bioinformatics analysis, luciferase reporter, RNA pull-down and RNA immunoprecipitation assays. The clinicopathologic features of and its target miRNA were analyzed in HNSCC. , a competing endogenous RNA, promoted cell proliferation, migration, invasion and epithelial-mesenchymal transition by sponging in HNSCC. Dysregulation of and mediated the effect of due to exhaustion. The and combination can accurately diagnose HNSCC. The and combination could be a valuable diagnostic and prognostic predictor for HNSCC.