Department of Oral & Maxillofacial-Head & Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, PR China.
Department of Dentistry, Affiliated Hospital, Weifang Medical University, Weifang 261031, PR China.
Epigenomics. 2020 Mar;12(6):487-505. doi: 10.2217/epi-2019-0173. Epub 2020 Apr 8.
To explore the biological functions and clinicopathologic significance of the long noncoding RNA in head and neck squamous cell carcinoma (HNSCC). We assessed the effects of and identified the target miRNA by bioinformatics analysis, luciferase reporter, RNA pull-down and RNA immunoprecipitation assays. The clinicopathologic features of and its target miRNA were analyzed in HNSCC. , a competing endogenous RNA, promoted cell proliferation, migration, invasion and epithelial-mesenchymal transition by sponging in HNSCC. Dysregulation of and mediated the effect of due to exhaustion. The and combination can accurately diagnose HNSCC. The and combination could be a valuable diagnostic and prognostic predictor for HNSCC.
探讨长链非编码 RNA 在头颈部鳞状细胞癌（HNSCC）中的生物学功能和临床病理意义。我们评估了的作用，并通过生物信息学分析、荧光素酶报告基因、RNA 下拉和 RNA 免疫沉淀实验鉴定了其靶 miRNA。分析了 HNSCC 中 及其靶 miRNA 的临床病理特征。作为竞争性内源性 RNA，通过海绵吸附 在 HNSCC 中促进细胞增殖、迁移、侵袭和上皮-间充质转化。由于 的耗竭， 与 的失调介导了 的作用。和 的组合可以准确诊断 HNSCC。和 的组合可能是 HNSCC 有价值的诊断和预后预测指标。
