Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, The Mærsk Tower, The Panum Institute, 2200 Copenhagen, Denmark; Department of Biology, Faculty of Science, University of Copenhagen, 2100 Copenhagen, Denmark.
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, The Mærsk Tower, The Panum Institute, 2200 Copenhagen, Denmark.
Cell Metab. 2020 Apr 7;31(4):666-668. doi: 10.1016/j.cmet.2020.03.001.
Lactate accumulation in tumors-a hallmark of the Warburg effect-has recently been shown to regulate cancer cell metabolism and survival through autocrine activation of GPR81. Now, Brown et al. (2020) demonstrate that lactate surprisingly also controls immune evasion through paracrine activation of GPR81 on stromal dendritic cells.
肿瘤中乳酸的积累——沃伯格效应的一个标志——最近被表明通过自分泌激活 GPR81 来调节癌细胞代谢和存活。现在，Brown 等人。（2020 年）表明，乳酸通过 GPR81 在上皮树突状细胞上的旁分泌激活，出人意料地也控制了免疫逃逸。
