College of Pharmacy, Zunyi Medical University, Zunyi, 563000, China; Joint International Research Laboratory of Ethnomedicine of Chinese Ministry of Education, Zunyi Medical University, Zunyi, 563000, China.
College of Pharmacy, Zunyi Medical University, Zunyi, 563000, China.
J Ethnopharmacol. 2020 Jul 15;257:112839. doi: 10.1016/j.jep.2020.112839. Epub 2020 Apr 5.
Dendrobium Nobile Lindl. (DNL) is one of the central herbs in traditional Chinese medicine which mainly distributes in Guizhou, Yunnan, Guangxi and other sub-tropical areas south of the Yangtze River. In the past decades, it has been used to treat tumors, hyperglycemia, hyperlipidemia, and diseases of the nervous system that may be caused by aging.
The purpose of this review is to summarize the anti-aging information of DNL from the molecular mechanism level, including classic theories related to aging, main chemical components, pharmacological research and anti-aging theory based on traditional Chinese medicine theory, for exploring the future development and clinical treatment.
The information in this paper has been collected from the scientific literature databases including PubMed, Google Scholar, Web of Science, Science Direct, Springer, China National Knowledge Infrastructure, published books, Ph.D. and M.S. dissertations systematically.
In this paper, we have reviewed the several mechanisms underlying the potential effects of DNL on the prevention of aging, including the scavenging of free radicals for oxidation, delaying of DNA impairment, inhibition of apoptosis, and alteration of DNA methylation. Together with the theory of telomeres, this review also has summarized recent research progress in the use of DNL and its traditional efficacy.
We conclude that "strengthening Yin and benefiting the spirit", "thickening the intestine and stomach", "lightning the body and prolonging the life-span", and delaying aging, are key effects of DNL that can be used to combat age-related diseases (ARDs) such as Alzheimer's disease, hyperlipidemia, and diabetes. This review provides a reference for future study of ARDs and the clinical application of DNL.
铁皮石斛（DNL）是中药的主要草药之一，主要分布在贵州、云南、广西等长江以南亚热带地区。在过去几十年中，它已被用于治疗肿瘤、高血糖、高血脂和可能由衰老引起的神经系统疾病。
本综述的目的是从分子机制水平总结 DNL 的抗衰老信息，包括与衰老相关的经典理论、主要化学成分、药理学研究以及基于中医理论的抗衰老理论，为探索未来的发展和临床治疗提供参考。
本文的信息是从包括 PubMed、Google Scholar、Web of Science、Science Direct、Springer、中国国家知识基础设施、出版书籍、博士和硕士论文在内的科学文献数据库中系统收集的。
在本文中，我们综述了 DNL 对预防衰老的潜在作用的几种机制，包括清除自由基氧化、延缓 DNA 损伤、抑制细胞凋亡和改变 DNA 甲基化。结合端粒理论，本综述还总结了 DNL 及其传统功效的最新研究进展。
我们的结论是，“滋阴养精”、“厚肠胃”、“轻身延年”、延缓衰老，是 DNL 对抗与年龄相关的疾病（ARDs）如阿尔茨海默病、高血脂和糖尿病的关键作用。本综述为未来的 ARD 研究和 DNL 的临床应用提供了参考。
