Department of Health, Human Performance and Recreation, Baylor University, One Bear Place #97313 Waco, TX 76706, USA.
Robbins College of Health and Human Sciences, Baylor University, One Bear Place #97313 Waco, TX 76706, USA.
Nutrients. 2020 Apr 6;12(4):1007. doi: 10.3390/nu12041007.
Novel approaches to ameliorating chronic kidney disease (CKD) are warranted as most patients are undiagnosed until they begin displaying symptoms of kidney failure. There is increasing evidence that a whole food plant-based (WFPB) diet may offer benefits that slow the progression of CKD, decrease the incidence cardiovascular disease, decrease rates of diabetes and obesity, and reduce inflammation and cholesterol, which in turn can delay kidney failure and the initiation of dialysis. While animal-based protein ingestion promotes an acidic environment, inflammation and renal hyperfiltration, study authors report plant-based protein can be alkaline-producing and anti-inflammatory and can contain renoprotective properties. Although there may be benefits to adopting a WFPB diet, macronutrient and micronutrient content should be carefully considered and adjusted to avoid malnutrition in CKD patients. Further research needs to be done in order to establish the biological plausibility and feasibility of a WFPB in individuals with diagnosed CKD.
需要探索新方法来改善慢性肾脏病 (CKD)，因为大多数患者在出现肾功能衰竭症状之前都未被诊断出来。越来越多的证据表明，全食物植物性 (WFPB) 饮食可能具有减缓 CKD 进展、降低心血管疾病发病率、降低糖尿病和肥胖率以及减少炎症和胆固醇的益处，这反过来又可以延缓肾衰竭和透析的开始。虽然动物蛋白摄入会促进酸性环境、炎症和肾脏高滤过，但研究作者报告称，植物蛋白可以产生碱性、具有抗炎作用，并且可能具有肾脏保护特性。虽然采用 WFPB 饮食可能有益，但应仔细考虑并调整宏量营养素和微量营养素的含量，以避免 CKD 患者发生营养不良。为了确定在诊断出 CKD 的个体中 WFPB 的生物学合理性和可行性，还需要进一步研究。
