Sandlund Johanna, Davies Kerrie, Wilcox Mark H
Fluxus, Inc., Santa Clara, California, USA.
Healthcare Associated Infections Research Group, Leeds Teaching Hospitals NHS Trust and University of Leeds, Leeds, United Kingdom.
J Clin Microbiol. 2020 May 26;58(6). doi: 10.1128/JCM.01913-19.
Currently available diagnostic tests for infection (CDI) lack specificity or sensitivity, which has led to guideline recommendations for multistep testing algorithms. Ultrasensitive assays for detection of toxins provide measurements of disease-specific markers at very low concentrations. These assays may show improved accuracy compared to that of current testing methods and offer a potential standalone solution for CDI diagnosis, although large studies of clinical performance and accuracy are lacking.
目前可用的艰难梭菌感染(CDI)诊断测试缺乏特异性或敏感性,这导致了对多步骤测试算法的指南建议。用于检测毒素的超灵敏测定法能够在非常低的浓度下测量疾病特异性标志物。与当前的测试方法相比,这些测定法可能显示出更高的准确性,并为CDI诊断提供了一种潜在的独立解决方案,尽管缺乏关于临床性能和准确性的大型研究。