烯丙氧羰基作为保护基团在寡脱氧核糖核苷酸合成中的应用。
Application of allyloxycarbonyl group as a protecting group to oligodeoxyribonucleotide synthesis.
作者信息
Mitsuhira Y, Tahara S, Goto K, Hayakawa Y, Noyori R
机构信息
Biological Science Institute, Nippon Zeon Co. Ltd., Kanagawa, Japan.
出版信息
Nucleic Acids Symp Ser. 1988(19):25-8.
PMID:3226919
Abstract
The allyloxycarbonyl (AOC) group, known as an efficient amino protective group in solution-phase synthesis of nucleotides, has been used for the first time in solid-phase oligonucleotide synthesis. The efficiency of the new procedure is compared with that of the conventional N-acyl protection.
摘要
烯丙氧羰基（AOC）基团，在核苷酸的溶液相合成中作为一种有效的氨基保护基团为人所知，首次被用于固相寡核苷酸合成。将新方法的效率与传统的N - 酰基保护方法的效率进行了比较。
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