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基于病例的铁过载综述，重点关注迟发性皮肤卟啉病、丙型肝炎、C282Y杂合性和冠状动脉疾病。

A Case-Based Review of Iron Overload With an Emphasis on Porphyria Cutanea Tarda, Hepatitis C, C282Y Heterozygosity, and Coronary Artery Disease.

作者信息

Hashemi Leila, Nisenbaum Robert

机构信息

is the Ambulatory Care Clerkship Director and an Attending Physician, Ambulatory Care Medicine; and is an Attending Physician, Ambulatory Care Medicine, both at the West Los Angeles VA Medical Center in California. Leila Hashesmi and Robert Nisenbaum are Assistant Professors of Clinical Medicine at the David Geffen School of Medicine at University of California, Los Angeles.

出版信息

Fed Pract. 2020 Feb;37(2):95-100.

PMID:32269472
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7138343/
Abstract

Iron overload can impact disease progression and treatment options for patients with comorbid conditions, such as porphyria cutanea tarda, hepatitis C virus, and coronary artery disease.

摘要

铁过载会影响患有共病（如迟发性皮肤卟啉症、丙型肝炎病毒和冠状动脉疾病）患者的疾病进展和治疗选择。

相似文献

1
A Case-Based Review of Iron Overload With an Emphasis on Porphyria Cutanea Tarda, Hepatitis C, C282Y Heterozygosity, and Coronary Artery Disease.基于病例的铁过载综述，重点关注迟发性皮肤卟啉病、丙型肝炎、C282Y杂合性和冠状动脉疾病。
Fed Pract. 2020 Feb;37(2):95-100.
2
[Role of the hemochromatosis gene in prophyria cutanea tarda. Prospective study of 56 cases].[血色素沉着症基因在迟发性皮肤卟啉症中的作用。56例前瞻性研究]
Ann Dermatol Venereol. 2001 May;128(5):600-4.
3
The C282Y mutation in the haemochromatosis gene (HFE) and hepatitis C virus infection are independent cofactors for porphyria cutanea tarda in Australian patients.血色素沉着症基因（HFE）中的C282Y突变和丙型肝炎病毒感染是澳大利亚患者迟发性皮肤卟啉症的独立辅助因素。
J Hepatol. 1998 Mar;28(3):404-9. doi: 10.1016/s0168-8278(98)80313-9.
4
High prevalence of hepatitis C virus type 1b in Italian patients with Porphyria cutanea tarda.意大利迟发性皮肤卟啉病患者中1b型丙型肝炎病毒的高流行率。
Ital J Gastroenterol Hepatol. 1997 Dec;29(6):543-7.
5
The prevalence of HFE C282Y gene mutation is increased in Spanish patients with porphyria cutanea tarda without hepatitis C virus infection.在西班牙患有迟发性皮肤卟啉症且无丙型肝炎病毒感染的患者中，HFE C282Y基因突变的患病率有所增加。
J Eur Acad Dermatol Venereol. 2006 Nov;20(10):1201-6. doi: 10.1111/j.1468-3083.2006.01746.x.
6
Porphyria cutanea tarda in Brazilian patients: association with hemochromatosis C282Y mutation and hepatitis C virus infection.巴西患者的迟发性皮肤卟啉症：与C282Y基因突变型血色素沉着症及丙型肝炎病毒感染的关联
Am J Gastroenterol. 2000 Dec;95(12):3516-21. doi: 10.1111/j.1572-0241.2000.03369.x.
7
[Significance and prevalence of the C282Y gene mutation of primary hemochromatosis in the pathogenesis of pophyria cutanea tarda].[原发性血色素沉着症C282Y基因突变在迟发性皮肤卟啉病发病机制中的意义及患病率]
Cas Lek Cesk. 2000 Nov 22;139(23):728-30.
8
Association of porphyria cutanea tarda with hereditary hemochromatosis.迟发性皮肤卟啉症与遗传性血色素沉着症的关联。
J Am Acad Dermatol. 2004 Aug;51(2):205-11. doi: 10.1016/j.jaad.2003.08.015.
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Genetic hemochromatosis in Italian patients with porphyria cutanea tarda: possible explanation for iron overload.迟发性皮肤卟啉症意大利患者中的遗传性血色素沉着症：铁过载的可能解释。
J Hepatol. 1996 May;24(5):564-9. doi: 10.1016/s0168-8278(96)80141-3.
10
Hepatitis C virus and porphyria cutanea tarda: evidence of a strong association.丙型肝炎病毒与迟发性皮肤卟啉症：强关联证据
Hepatology. 1992 Dec;16(6):1322-6. doi: 10.1002/hep.1840160603.

本文引用的文献

1
Porphyria cutanea tarda: Recent update.迟发性皮肤卟啉病：最新进展。
Mol Genet Metab. 2019 Nov;128(3):271-281. doi: 10.1016/j.ymgme.2019.01.004. Epub 2019 Jan 18.
2
Improvement of porphyria cutanea tarda following treatment of hepatitis C virus by direct-acting antivirals: A case report.直接作用抗病毒药物治疗丙型肝炎病毒后迟发性皮肤卟啉症的改善：一例报告
J Dermatol. 2019 May;46(5):e149-e151. doi: 10.1111/1346-8138.14716. Epub 2018 Dec 3.
3
Hepatitis C Treatment in Patients With Porphyria Cutanea Tarda.迟发性皮肤卟啉病患者的丙型肝炎治疗
Am J Med Sci. 2017 Jun;353(6):523-528. doi: 10.1016/j.amjms.2017.03.007. Epub 2017 Mar 8.
4
Direct-acting antivirals for hepatitis C virus induce a rapid clinical and biochemical remission of porphyria cutanea tarda.丙型肝炎病毒直接作用抗病毒药物可迅速诱导迟发性皮肤卟啉症出现临床和生化缓解。
Br J Dermatol. 2017 Nov;177(5):e183-e184. doi: 10.1111/bjd.15502. Epub 2017 Sep 26.
5
Hepatitis C virus and its cutaneous manifestations: treatment in the direct-acting antiviral era.丙型肝炎病毒及其皮肤表现：直接作用抗病毒时代的治疗。
J Eur Acad Dermatol Venereol. 2017 Aug;31(8):1260-1270. doi: 10.1111/jdv.14186. Epub 2017 Mar 29.
6
The relation between body iron store and ferritin, and coronary artery disease.体内铁储备与铁蛋白和冠状动脉疾病之间的关系。
ARYA Atheroscler. 2014 Jan;10(1):32-6.
7
Hepatitis C, porphyria cutanea tarda and liver iron: an update.丙型肝炎、迟发性皮肤卟啉病和肝铁：最新进展。
Liver Int. 2012 Jul;32(6):880-93. doi: 10.1111/j.1478-3231.2012.02794.x. Epub 2012 Apr 17.
8
Iron overload in HFE C282Y heterozygotes at first genetic testing: a strategy for identifying rare HFE variants.初次基因检测时 HFE C282Y 杂合子中的铁过载：一种鉴定罕见 HFE 变异体的策略。
Haematologica. 2011 Apr;96(4):507-14. doi: 10.3324/haematol.2010.029751. Epub 2011 Jan 12.
9
Association of porphyria cutanea tarda with hereditary hemochromatosis.迟发性皮肤卟啉症与遗传性血色素沉着症的关联。
J Am Acad Dermatol. 2004 Aug;51(2):205-11. doi: 10.1016/j.jaad.2003.08.015.
10
Haemochromatosis (HFE) gene C282Y mutation and the risk of coronary artery disease and myocardial infarction: a study in 1279 patients undergoing coronary angiography.血色素沉着症（HFE）基因C282Y突变与冠状动脉疾病和心肌梗死风险：一项对1279例接受冠状动脉造影患者的研究
J Med Genet. 2003 May;40(5):e58. doi: 10.1136/jmg.40.5.e58.