HDAC1和RBBP4的表达与乳腺癌的临床病理特征及预后相关。
Expression of HDAC1 and RBBP4 correlate with clinicopathologic characteristics and prognosis in breast cancer.
作者信息
Guo Qingqun, Cheng Kai, Wang Xiaohong, Li Xiaoqiang, Yu Yue, Hua Yitong, Yang Zhenlin
机构信息
Department of Thyroid and Breast Surgery, Binzhou Medical University Hospital Binzhou, Shandong, China.
出版信息
Int J Clin Exp Pathol. 2020 Mar 1;13(3):563-572. eCollection 2020.
Abstract
Retinoblastoma binding protein 4 (RBBP4) plays an important role in transcription, cell cycle, and proliferation. Immunohistochemistry was performed to assess HDAC1 and RBBP4 expression in 240 BC patients. The expression of HDAC1 and RBBP4 in 12 pairs of BC tissues and their normal tissues was determined by western blotting. Kaplan-Meier analysis and Cox's proportional hazards regression were applied to evaluate the prognostic significance of HDAC1 and RBBP4. HDAC1 and RBBP4 expression in BC was significantly higher than that in normal tissues. HDAC1 was positively correlated with RBBP4 in breast cancer. HDAC1 and RBBP4 were negatively correlated with ER and PR in BC, respectively. The patients with high expression of RBBP4 had a worse overall survival time. The expression of RBBP4 was found to be significantly correlated with lymph node metastasis. RBBP4 may play a major role though HDAC1 in the development, metastasis, and prognosis of BC.
摘要
视网膜母细胞瘤结合蛋白4（RBBP4）在转录、细胞周期和增殖过程中发挥着重要作用。对240例乳腺癌患者进行免疫组织化学检测，以评估HDAC1和RBBP4的表达情况。通过蛋白质印迹法测定12对乳腺癌组织及其正常组织中HDAC1和RBBP4的表达。应用Kaplan-Meier分析和Cox比例风险回归评估HDAC1和RBBP4的预后意义。乳腺癌中HDAC1和RBBP4的表达显著高于正常组织。在乳腺癌中，HDAC1与RBBP4呈正相关。在乳腺癌中，HDAC1和RBBP4分别与雌激素受体（ER）和孕激素受体（PR）呈负相关。RBBP4高表达的患者总生存时间较差。发现RBBP4的表达与淋巴结转移显著相关。RBBP4可能通过HDAC1在乳腺癌的发生、转移和预后中发挥主要作用。
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