性别对喉鳞状细胞癌患者生存的影响：一项倾向评分匹配分析。
Impact of gender on survival in patients with laryngeal squamous cell carcinoma: a propensity score matching analysis.
作者信息
Wang Na, Lv Hong, Huang Ming
机构信息
Department of Otolaryngology Medical School of Facial Sciences, Hubei University of Science and Technology Xianning, China.
School of Nursing, Hubei University of Science and Technology Xianning, China.
出版信息
Int J Clin Exp Pathol. 2020 Mar 1;13(3):573-581. eCollection 2020.
BACKGROUND
In the world, there are approximately 160,000 cases of laryngeal cancer newly diagnosed every year and 95% of the cases are squamous cell carcinoma (LSCC). We conduct this study to investigate the influencing factors in LSCC.
METHOD
We used cohort of LSCC cases form the Surveillance, Epidemiology, and End Results (SEER) database (1973-2014) to investigate the relationship between gender and survival. We conducted 1:1 propensity matching to mimic randomized controlled trials. Using the matched group, we investigate the effect of gender on cancer-specific survival (CSS) and overall survival (OS).
RESULT
In total, 47881 patients were brought into an unmatched cohort and 17985 cases were brought into a matched cohort. Using the matched group, we conducted a survival analysis. The 1-year, 3-year, and 5-year CSS and OS rates were better in female patients and the subgroup analysis showed the same trend. Cox regression analysis showed gender was an independent prognostic indicator for LSCC patients.
CONCLUSION
Gender is an independent prognostic indicator for LSCC patients. Male patients are a high-risk population.
背景
全球每年约有16万例喉癌新发病例，其中95%为鳞状细胞癌（LSCC）。我们开展本研究以调查LSCC的影响因素。
方法
我们使用监测、流行病学和最终结果（SEER）数据库（1973 - 2014年）中的LSCC病例队列来研究性别与生存率之间的关系。我们进行1:1倾向匹配以模拟随机对照试验。利用匹配组，我们研究性别对癌症特异性生存率（CSS）和总生存率（OS）的影响。
结果
总共47881例患者被纳入未匹配队列，17985例被纳入匹配队列。利用匹配组，我们进行了生存分析。女性患者的1年、3年和5年CSS及OS率更高，亚组分析显示了相同趋势。Cox回归分析表明性别是LSCC患者的独立预后指标。
结论
性别是LSCC患者的独立预后指标。男性患者是高危人群。
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