Bi Feifei, Wang Qiwei, Dong Qian, Wang Yuanhe, Zhang Liqun, Zhang Jingdong
Medical Oncology Department of Gastrointestinal Cancer, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute Shenyang, China.
Am J Transl Res. 2020 Mar 15;12(3):1044-1055. eCollection 2020.
Tumor biopsy is the standard method for cancer diagnosis and provides an important sample for pathological assessment. With the development of precision medicine, liquid biopsies are now an important tool to detect molecular changes and tumor heterogeneity. In recent years, research related to circulating tumor DNA (ctDNA) has intensified due to its non-invasive, convenient, comprehensive, and safety characteristics. Herein, we provide a review describing the clinical applications and prospects of ctDNA in colorectal cancer (CRC) diagnosis, monitoring and prognosis.
肿瘤活检是癌症诊断的标准方法，为病理评估提供重要样本。随着精准医学的发展，液体活检现已成为检测分子变化和肿瘤异质性的重要工具。近年来，由于循环肿瘤DNA（ctDNA）具有非侵入性、便捷、全面和安全的特点，与之相关的研究不断加强。在此，我们提供一篇综述，描述ctDNA在结直肠癌（CRC）诊断、监测和预后方面的临床应用及前景。
