Department of Cardiology, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China.
Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects & Related Diseases of Women & Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Biomark Med. 2020 Apr;14(6):441-450. doi: 10.2217/bmm-2019-0384. Epub 2020 Apr 9.
The present study aimed to investigate the role of gene polymorphisms in dilated cardiomyopathy (DCM) susceptibility and prognosis in a Chinese population. A total of 343 DCM patients and 451 controls were enrolled and had their blood genotyped. Survival analysis was evaluated with Kaplan-Meier curves and Cox regression analysis. G carriers (AG/GG) and AG genotype of rs237028 had a higher DCM susceptibility as well as a worse DCM prognosis. Additionally, C carriers (CT/CC) of rs652921 and G carriers (TG/GG) of rs521845 had a higher DCM risk and CC homozygote of rs652921 had a worse DCM prognosis. These associations were still significant after adjustment for the Bonferroni correction. gene polymorphisms were associated with DCM susceptibility and prognosis in the Chinese population.
本研究旨在探讨基因多态性在中国人群中对扩张型心肌病（DCM）易感性和预后的作用。共纳入 343 例 DCM 患者和 451 例对照，并对其血液进行基因分型。采用 Kaplan-Meier 曲线和 Cox 回归分析评估生存分析。rs237028 的 G 携带者（AG/GG）和 AG 基因型具有更高的 DCM 易感性和更差的 DCM 预后。此外，rs652921 的 C 携带者（CT/CC）和 rs521845 的 G 携带者（TG/GG）具有更高的 DCM 风险，rs652921 的 CC 纯合子具有更差的 DCM 预后。这些关联在经过 Bonferroni 校正后仍然显著。基因多态性与中国人群的 DCM 易感性和预后相关。
