Department of Pathology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects & Related Diseases of Women & Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Dis Markers. 2019 Aug 14;2019:8012979. doi: 10.1155/2019/8012979. eCollection 2019.
Epithelial ovarian cancer (EOC) is highly lethal worldwide. Factors involved in the inflammation and hormone-associated signaling pathway play vital roles in EOC carcinogenesis. The transforming growth factor-- (TGF--) activated kinase 1 (MAP3K7) binding protein 2 (), mediating convergence of inflammatory and estrogen, may be implicated in EOC. The present study is aimed at exploring the association between the gene polymorphisms and EOC.
Three single nucleotide polymorphisms (SNPs) (rs237028, rs521845, and rs652921) of were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 221 patients and 252 healthy controls. Associations between SNPs and clinical characteristics were performed either with the test or with Fisher's exact test. The Kaplan-Meier method and Cox proportional hazard models were used to detect associations between genotypes and overall survival.
The rs237028 polymorphism was significantly associated with an increased risk of EOC with an allelic genetic model (A G; OR = 1.45; 95%CI = 1.07-1.96; = 0.016), dominant genetic model (AA AG-GG; OR = 1.66; CI 1.14-2.41; = 0.008), and overdominant genetic model (AA-GG AG; OR = 1.60; CI 1.08-2.36; = 0.017). However, no significant association was observed between rs237028 polymorphism and overall survival.
Our study indicated that the rs237028 polymorphism in the gene was associated with EOC susceptibility and the gene might contribute to the initiation of EOC.
上皮性卵巢癌（EOC）在全球范围内具有很高的致死率。参与炎症和激素相关信号通路的因素在 EOC 癌变中起着至关重要的作用。转化生长因子--（TGF-）激活激酶 1（MAP3K7）结合蛋白 2（），介导炎症和雌激素的收敛，可能与 EOC 有关。本研究旨在探讨基因多态性与 EOC 之间的关系。
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法检测 221 例患者和 252 例健康对照者中基因的 3 个单核苷酸多态性（SNP）（rs237028、rs521845 和 rs652921）。采用卡方检验或 Fisher 确切概率法分析 SNP 与临床特征的关系。采用 Kaplan-Meier 法和 Cox 比例风险模型检测基因型与总生存时间的关系。
rs237028 多态性与 EOC 的发病风险增加显著相关，等位基因遗传模型（A G；OR = 1.45；95%CI = 1.07-1.96； = 0.016）、显性遗传模型（AA AG-GG；OR = 1.66；CI 1.14-2.41； = 0.008）和超显性遗传模型（AA-GG AG；OR = 1.60；CI 1.08-2.36； = 0.017）。然而，rs237028 多态性与总生存时间无显著相关性。
本研究表明，基因中的 rs237028 多态性与 EOC 的易感性有关，该基因可能有助于 EOC 的发生。
