Johnson L R
Cancer. 1981 Mar 15;47(6 Suppl):1640-5. doi: 10.1002/1097-0142(19810315)47:6+<1640::aid-cncr2820471430>3.0.co;2-s.
This article discusses experiments demonstrating that the gastrointestinal hormones, gastrin, secretin, and CCK (cholecystokinin), stimulate the growth of the exocrine pancreas. Exogenous gastrin, secretin, and CCK increase pancreatic weight DNA, RNA and protein content of the rat pancreas. Antrectomy, which removes most endogenous gastrin, decreases pancreatic growth. The effects of antrectomy are prevented by exogenous gastrin. Infusion of HCl into the duodenum to release secretin and infusion of amino acids into the duodenum to release CCK also stimulate pancreatic growth. These results provide evidence that the regulation of pancreatic growth is an important action of the gastrointestinal hormones.
本文讨论了一些实验，这些实验表明胃肠激素，即胃泌素、促胰液素和缩胆囊素（CCK），能刺激外分泌胰腺的生长。外源性胃泌素、促胰液素和缩胆囊素可增加大鼠胰腺的重量、DNA、RNA和蛋白质含量。切除大部分内源性胃泌素的胃窦切除术会降低胰腺生长。外源性胃泌素可预防胃窦切除术的影响。向十二指肠内注入盐酸以释放促胰液素，以及向十二指肠内注入氨基酸以释放缩胆囊素，也能刺激胰腺生长。这些结果证明，胰腺生长的调节是胃肠激素的一项重要作用。
