State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Novogene Bioinformatics Institute, Beijing 100083, PR China.
Science. 2020 May 22;368(6493). doi: 10.1126/science.aba5435. Epub 2020 Apr 9.
head blight (FHB), a fungal disease caused by species that produce food toxins, currently devastates wheat production worldwide, yet few resistance resources have been discovered in wheat germplasm. Here, we cloned the FHB resistance gene by assembling the genome of , a species used in wheat distant hybridization breeding. encodes a glutathione S-transferase (GST) and confers broad resistance to species by detoxifying trichothecenes through de-epoxidation. GST homologs are absent in plants, and our evidence supports that has gained through horizontal gene transfer (HGT) from an endophytic species. introgressions in wheat confers resistance to both FHB and crown rot in diverse wheat backgrounds without yield penalty, providing a solution for resistance breeding.
小麦赤霉病（FHB）是由产生食物毒素的 物种引起的真菌病害，目前在全球范围内严重破坏小麦生产，但在小麦种质资源中发现的抗性资源很少。在这里，我们通过组装用于小麦远缘杂交育种的物种的基因组，克隆了 FHB 抗性基因 。 编码谷胱甘肽 S-转移酶（GST），通过脱环氧作用解毒单端孢霉烯族化合物，赋予对 物种的广泛抗性。GST 同源物在植物中不存在，我们的证据支持 通过来自内生 物种的水平基因转移（HGT）获得了 。在不同小麦背景下， 在小麦中的导入既赋予了对赤霉病和茎基腐病的抗性，又没有产量损失，为 抗性育种提供了一种解决方案。
