Solov'ena N N, Belousova I I, Tereshin I M
Biokhimiia. 1977 Feb;42(2):277-82.
Polyenic antibiotics (levorin, amphotericin B, nistatin) inhibit in vivo and in vitro the activity of membrane alkaline phosphatase from sensitive Candida albicans strain, and their inhibitory effect is twice lower on the enzyme from the resistant strain. A correlation is observed between the antibiotic concentration and the inhibitory effect on alkaline phosphatase activity. Nistatin is found to be the least efficient inhibitor (among the antibiotics studied) of alkaline phosphatase. The treatment of membranes with polyenic antibiotics does not result in solubilization of membrane proteins nad alkaline phosphatase. The data obtained are considered with respect to the effect of polyenic antibiotics on cell membrane structure.
多烯类抗生素（制霉菌素、两性霉素B、里窝那霉素）在体内和体外均能抑制敏感白色念珠菌菌株的膜碱性磷酸酶活性，而对耐药菌株的该酶抑制作用则低两倍。观察到抗生素浓度与对碱性磷酸酶活性的抑制作用之间存在相关性。发现制霉菌素（在所研究的抗生素中）是碱性磷酸酶最无效的抑制剂。用多烯类抗生素处理膜不会导致膜蛋白和碱性磷酸酶溶解。就多烯类抗生素对细胞膜结构的影响而言，对所获得的数据进行了考量。
