Panduranga Shenoy Revathi, Hanumaiah Gagana, Bolar Suryakanth Varashree, Shridharan Priyanka
Department of Biochemistry, Kasturba Medical College Manipal, Manipal Academy of Higher Education Manipal, Karnataka, India.
Rep Biochem Mol Biol. 2019 Oct;8(3):253-259.
The study aims at the comparison and correlation of serum levels of fructosamine and erythrocyte Na/ K ATPase in Gestational diabetes mellitus (GDM) and Non Gestational Diabetes Mellitus (Non GDM).
A total of 326 samples were divided into 4 groups. Pregnant women between the age group of 2040 years who gave samples for Oral Glucose Tolerance Test (OGTT) were included as the subjects. Anonymized and left over fasting and 2 hours' samples were collected from biochemistry laboratory, Kasturba Hospital, Manipal.
In the comparison of fructosamine levels in GDM and Non GDM, fructosamine was found to be significant (p value<0.001) in both fasting and 2 hours (G2) blood glucose condition. Na/ K ATPase did not show any significant variation between the groups.Correlation was not significant between the parameters.
Fructosamine showed significant increase when compared between the groups, whereas significant correlation is not obtained between the parameters. Thus, the use fructosamine as a diagnosis tool becomes inconclusive. Further studies must be carried out to identify a marker which reduces the interferences observed in fructosamine and to find out the exact relationship between hyperglycaemia and Na/ K ATPase activity.
本研究旨在比较和关联妊娠期糖尿病（GDM）和非妊娠期糖尿病（非GDM）患者血清果糖胺水平与红细胞钠/钾ATP酶水平。
共326份样本被分为4组。纳入年龄在20至40岁之间、提供口服葡萄糖耐量试验（OGTT）样本的孕妇作为研究对象。从马尼帕尔卡斯图尔巴医院生化实验室收集匿名的空腹及2小时剩余样本。
在比较GDM和非GDM患者的果糖胺水平时，发现无论是空腹还是2小时（G2）血糖情况下，果糖胺均具有显著性差异（p值<0.001）。各组间钠/钾ATP酶未显示出任何显著差异。各参数之间的相关性不显著。
组间比较时果糖胺显著升高，而各参数之间未获得显著相关性。因此，将果糖胺用作诊断工具尚无定论。必须开展进一步研究以确定一种能减少果糖胺中观察到的干扰的标志物，并找出高血糖与钠/钾ATP酶活性之间的确切关系。
