Dominguez-Rodriguez A, Chavez-Valdez S M, Avitia G C, Valencia-Espinoza L C
Faculty of Medicine and Psychology, Autonomous University of Baja California, Calzada Universidad 14418, Parque Industrial Internacional Tijuana, Tijuana, B.C, 22427, Mexico.
Faculty of Psychology, Escuela Libre de Psicología, A.C. ELPAC-Universidad de Ciencias del Comportamiento, ELPAC University of Behavioral Sciences, Calle Pedro Zuloaga #8805, Colonia Labor de Terrazas, Chihuahua, Chih, 31207, Mexico.
Contemp Clin Trials Commun. 2020 Mar 17;18:100556. doi: 10.1016/j.conctc.2020.100556. eCollection 2020 Jun.
The Unified Protocol for Emotional Disorders (UP) for emotional regulation manifests effective results in a broad range of mental disorders. The UP efficacy was tested in several countries, but it has not been tested within Mexican population. It is crucial to do more research and implement effective protocols to intervene Mexican population with Anxiety Disorders (AD).
This study aims to examine and describe the research procedures and treatment interventions of the UP in a Randomized Controlled Trial (RCT), to approach and treat AD in patients in 2 Mexican borderland cities, by applying the UP and an Electroencephalogram (EGG) neuro screening.
The enrolled patients will be randomized in a two-arm control trial with repeated measures, comprising between 18 and 60 years, that were diagnosed with an AD, and low scored in depression symptoms and suicidal ideation. The study will comprise of two conditions: an intervention group clinical trial with the UP or a waiting list control. The primary outcome measures will be applied on AD quantitative self-reports and a gamma activity by EGG before and after the intervention and in follow-ups of 3 and 6 months. The participants in the waiting list group, will receive the treatment after the trial first group completes the treatment.
Processes and outcomes of this project, will provide evidence in order to apply the UP in a broader population with AD and other mental disorders also covered by this protocol, such as depression and borderline personality disorder in a broader Mexican population, a country that suffers with a major health issue with an increasing rate of mental disorders and scarce psychological and health coverage.
情绪障碍统一方案（UP）在情绪调节方面对广泛的精神障碍显示出有效结果。UP的疗效已在多个国家进行了测试，但尚未在墨西哥人群中进行测试。开展更多研究并实施有效的方案来干预患有焦虑症（AD）的墨西哥人群至关重要。
本研究旨在通过一项随机对照试验（RCT）来检验和描述UP的研究程序及治疗干预措施，通过应用UP和脑电图（EEG）神经筛查，对墨西哥两个边境城市的患者的AD进行评估和治疗。
纳入的患者将被随机分配到一个双臂对照试验中，该试验采用重复测量，患者年龄在18至60岁之间，被诊断患有AD，且抑郁症状和自杀意念得分较低。该研究将包括两种情况：采用UP的干预组临床试验或等待名单对照组。主要结局指标将应用于AD定量自我报告以及干预前后、3个月和6个月随访时EEG的γ活动。等待名单组的参与者将在试验的第一组完成治疗后接受治疗。
本项目的过程和结果将提供证据，以便在更广泛的患有AD以及该方案涵盖的其他精神障碍（如抑郁症和边缘性人格障碍）的墨西哥人群中应用UP，墨西哥是一个面临重大健康问题、精神障碍发病率不断上升且心理和医疗覆盖不足的国家
