Stroemel-Scheder Cindy, Kundermann Bernd, Lautenbacher Stefan
Physiological Psychology, University of Bamberg, Bamberg, Germany.
Vitos Clinic for Psychiatry and Psychotherapy Giessen, Giessen, Germany; Department of Psychiatry and Psychotherapy, Philipps-University of Marburg, Marburg, Germany.
Neurosci Biobehav Rev. 2020 Jun;113:408-425. doi: 10.1016/j.neubiorev.2020.03.028. Epub 2020 Apr 8.
Experimental studies highlight profound effects of sleep disruptions on pain, showing that sleep deprivation (SD) leads to hyperalgesic pain changes. On the other hand, given that sleep helps normalizing bodily functions, a crucial role of restorative sleep in the overnight restoration of the pain system seems likely. Thus, a systematic review of experimental studies on effects of recovery sleep (RS; subsequently to SD) on pain was performed with the aim to check whether RS resets hyperalgesic pain changes occurring due to SD. Empirical animal and human studies including SD-paradigms, RS and pain assessments were searched in three databases (PubMed, Web of Science, PsycINFO) using a predefined algorithm. 29 studies were included in this review. Most results indicated a reset of enhanced pain sensitivity and vulnerability following RS, especially when total SD was implemented and pressure pain or painful symptoms (human studies) were assessed. Further research should focus on whether and how recovery is altered in chronic pain patients, as this yields implications for pain treatment by enhancing or stabilizing RS.
实验研究凸显了睡眠中断对疼痛的深远影响，表明睡眠剥夺（SD）会导致痛觉过敏的疼痛变化。另一方面，鉴于睡眠有助于身体功能正常化，恢复性睡眠在夜间恢复疼痛系统中似乎起着关键作用。因此，我们对关于恢复性睡眠（RS；在SD之后）对疼痛影响的实验研究进行了系统综述，目的是检查RS是否能重置因SD而出现的痛觉过敏疼痛变化。我们使用预定义算法在三个数据库（PubMed、科学网、PsycINFO）中搜索了包括SD范式、RS和疼痛评估在内的实证动物和人体研究。本综述纳入了29项研究。大多数结果表明，RS后增强的疼痛敏感性和易损性会重置，尤其是在实施完全SD且评估压力疼痛或疼痛症状（人体研究）时。进一步的研究应关注慢性疼痛患者的恢复是否以及如何改变，因为这对通过增强或稳定RS来进行疼痛治疗具有启示意义。
