Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Republic of Korea; Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh.
Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh.
Phytomedicine. 2020 Apr;69:153201. doi: 10.1016/j.phymed.2020.153201. Epub 2020 Mar 8.
Marine algae are rich in some unique biologically active secondary metabolites having diverse pharmacological benefits. Of these, sterols comprise a group of functional lipid compounds that have attracted much attention to natural product scientists.
This review was aimed to update information on the health effects of algae-derived phytosterols and their molecular interactions in various aspects of human health and diseases and to address some future perspectives that may open up a new dimension of pharmacological potentials of algal sterols.
A literature-based search was carried out to retrieve published research information on the potential health effects of algal phytosterols with their pharmacological mechanisms from accessible online databases, such as Pubmed, Google Scholar, Web of Science, and Scopus, using the key search terms of 'marine algae sterol' and 'health potentials such as antioxidant or anti-inflammatory or anti-Alzheimer's or anti-obesity or cholesterol homeostasis or hepatoprotective, antiproliferative, etc.'
Phytosterols of marine algae, particularly fucosterol, have been investigated for a plethora of health benefits, including anti-diabetes, anti-obesity, anti-Alzheimer's, antiaging, anticancer, and hepatoprotection, among many others, which are attributed to their antioxidant, anti-inflammatory, immunomodulatory and cholesterol-lowering properties, indicating their potentiality as therapeutic leads. These sterols interact with enzymes and various other proteins that are actively participating in different cellular pathways, including antioxidant defense system, apoptosis and cell survival, metabolism, and homeostasis.
In this review, we briefly overview the chemistry, pharmacokinetics, and distribution of algal sterols, and provide critical insights into their potential health effects and the underlying pharmacological mechanisms, beyond the well-known cholesterol-lowering paradigm.
海洋藻类富含多种具有不同药理作用的独特生物活性次生代谢产物。其中，甾醇是一组功能性脂质化合物，引起了天然产物科学家的广泛关注。
本综述旨在更新有关藻类衍生植物甾醇对人类健康和疾病各个方面的健康影响及其分子相互作用的信息，并探讨一些未来的展望，这些展望可能为藻类甾醇的药理潜力开辟新的维度。
通过文献检索，从可访问的在线数据库（如 Pubmed、Google Scholar、Web of Science 和 Scopus）中检索关于藻类植物甾醇潜在健康影响及其药理学机制的已发表研究信息，使用的关键搜索词为“marine algae sterol”和“health potentials such as antioxidant or anti-inflammatory or anti-Alzheimer's or anti-obesity or cholesterol homeostasis or hepatoprotective, antiproliferative, etc.”。
海洋藻类的植物甾醇，特别是岩藻甾醇，已经被广泛研究用于多种健康益处，包括抗糖尿病、抗肥胖、抗阿尔茨海默病、抗衰老、抗癌和保肝等，这归因于其抗氧化、抗炎、免疫调节和降胆固醇特性，表明其作为治疗药物的潜力。这些甾醇与各种酶和其他蛋白质相互作用，这些酶和蛋白质积极参与不同的细胞途径，包括抗氧化防御系统、细胞凋亡和细胞存活、代谢和内稳态。
在本综述中，我们简要概述了藻类甾醇的化学、药代动力学和分布，并提供了关于其潜在健康影响及其潜在药理机制的关键见解，超越了众所周知的降胆固醇范式。
