Guedes Beatriz N, Krambeck Karolline, Durazzo Alessandra, Lucarini Massimo, Santini Antonello, Oliveira M Beatriz P P, Fathi Faezeh, Souto Eliana B
Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Porto, 4050-313, Portugal.
Health Sciences School, Guarda Polytechnic Institute, Rua da Cadeia, Guarda, 6300-035, Portugal.
Braz J Microbiol. 2024 Sep;55(3):2753-2766. doi: 10.1007/s42770-024-01410-1. Epub 2024 Jun 18.
The current burden associated to multidrug resistance, and the emerging superbugs, result in a decreased and even loss of antibiotic efficacy, which poses significant challenges in the treatment of infectious diseases. This situation has created a high demand for the discovery of novel antibiotics that are both effective and safe. However, while antibiotics play a crucial role in preventing and treating diseases, they are also associated with adverse effects. The emergence of multidrug-resistant and the extensive appearance of drug-resistant microorganisms, has become one of the major hurdles in healthcare. Addressing this problem will require the development of at least 20 new antibiotics by 2060. However, the process of designing new antibiotics is time-consuming. To overcome the spread of drug-resistant microbes and infections, constant evaluation of innovative methods and new molecules is essential. Research is actively exploring alternative strategies, such as combination therapies, new drug delivery systems, and the repurposing of existing drugs. In addition, advancements in genomic and proteomic technologies are aiding in the identification of potential new drug targets and the discovery of new antibiotic compounds. In this review, we explore new sources of natural antibiotics from plants, algae other sources, and propose innovative bioinspired delivery systems for their use as an approach to promoting responsible antibiotic use and mitigate the spread of drug-resistant microbes and infections.
当前与多重耐药性以及新出现的超级细菌相关的负担，导致抗生素疗效降低甚至丧失，这在传染病治疗中构成了重大挑战。这种情况使得人们对发现既有效又安全的新型抗生素产生了强烈需求。然而，尽管抗生素在预防和治疗疾病方面发挥着关键作用，但它们也会带来副作用。多重耐药性的出现以及耐药微生物的广泛出现，已成为医疗保健领域的主要障碍之一。到2060年，解决这一问题将需要研发至少20种新抗生素。然而，设计新抗生素的过程耗时较长。为了克服耐药微生物和感染的传播，持续评估创新方法和新分子至关重要。研究正在积极探索替代策略，如联合疗法、新型药物递送系统以及现有药物的重新利用。此外，基因组学和蛋白质组学技术的进步有助于识别潜在的新药物靶点和发现新的抗生素化合物。在本综述中，我们探索来自植物、藻类和其他来源的天然抗生素新来源，并提出创新的仿生递送系统，将其用作促进合理使用抗生素以及减轻耐药微生物和感染传播的一种方法。
