Banner David, Kelvin Alyson A
Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
J Infect Dev Ctries. 2012 Jun 15;6(6):465-9. doi: 10.3855/jidc.2666.
Highly pathogenic avian influenza H5N1 is a threat to global public health as a natural pandemic causing agent but has recently been considered a bioterrorism concern. The evolving view of the H5N1 virus necessitates the re-evaluation of the current status of H5N1 therapeutics and prophylactics, in particular the preparation of viable H5N1 vaccination strategies as well as the use of ferrets in influenza research. Here the highly pathogenic H5N1 virus dilemma is discussed in context with the current H5N1 vaccine status and the use of the ferret model. Previously, the development of various H5N1 vaccine platforms have been attempted, many of them tested in the ferret model, including vector vaccines, adjuvant vaccines, DNA vaccines, and reverse engineered vaccines. Moreover, as ferrets are a superlative animal model for influenza investigation and vaccine testing, it is imperative that this model is recognized for its uses in prophylactic development and not only as an agent for creating transmissible influenza viruses. Elucidating the ferret immune response and creating ferret immune reagents remain important goals in conjunction with the development and manufacture of H5N1 vaccines. In summary, an efficacious H5N1 vaccine is urgently needed and the ferret model remains an appropriate model for its development.
高致病性禽流感H5N1作为一种自然大流行致病因子，对全球公共卫生构成威胁，但最近被视为生物恐怖主义问题。对H5N1病毒不断演变的看法使得有必要重新评估H5N1治疗药物和预防药物的现状，特别是制定可行的H5N1疫苗接种策略以及在流感研究中使用雪貂。本文结合当前H5N1疫苗的现状和雪貂模型的使用，讨论了高致病性H5N1病毒的困境。此前，人们尝试开发了各种H5N1疫苗平台，其中许多在雪貂模型中进行了测试，包括载体疫苗、佐剂疫苗、DNA疫苗和反向工程疫苗。此外，由于雪貂是流感研究和疫苗测试的最佳动物模型，必须认识到该模型在预防性开发中的用途，而不仅仅是作为制造可传播流感病毒的工具。阐明雪貂的免疫反应并制备雪貂免疫试剂，仍然是与H5N1疫苗的开发和生产相关的重要目标。总之，迫切需要一种有效的H5N1疫苗，而雪貂模型仍然是其开发的合适模型。
