Sun Xiangjie, Belser Jessica A, Li Zhu-Nan, Brock Nicole, Pulit-Penaloza Joanna A, Kieran Troy J, Pappas Claudia, Zeng Hui, Chang Jessie C, Carney Paul J, Bradley-Ferrell Brandon L, Stevens James, Tumpey Terrence M, Levine Min Z, Maines Taronna R
Emerg Infect Dis. 2025 Mar;31(3):458-466. doi: 10.3201/eid3103.241489.
Reports of human infections with influenza A(H5N1) clade 2.3.4.4b viruses associated with outbreaks in dairy cows in the United States underscore the need to assess the potential cross-protection conferred by existing influenza immunity. We serologically evaluated ferrets previously infected with an influenza A(H1N1)pdm09 virus for cross-reactive antibodies and then challenged 3 months later with either highly pathogenic H5N1 clade 2.3.4.4b or low pathogenicity H7N9 virus. Our results showed that prior influenza A(H1N1)pdm09 virus infection more effectively reduced the replication and transmission of the H5N1 virus than did the H7N9 virus, a finding supported by the presence of group 1 hemagglutinin stalk and N1 neuraminidase antibodies in preimmune ferrets. Our findings suggest that prior influenza A(H1N1)pdm09 virus infection may confer some level of protection against influenza A(H5N1) clade 2.3.4.4.b virus.
关于美国与奶牛场疫情相关的甲型流感病毒（H5N1）2.3.4.4b分支毒株人类感染病例的报告，凸显了评估现有流感免疫力所提供的潜在交叉保护的必要性。我们对先前感染过甲型流感病毒（H1N1）pdm09毒株的雪貂进行了血清学评估，以检测其交叉反应抗体，然后在3个月后用高致病性H5N1 2.3.4.4b分支毒株或低致病性H7N9病毒进行攻击。我们的结果表明，与H7N9病毒相比，先前感染甲型流感病毒（H1N1）pdm09毒株能更有效地减少H5N1病毒的复制和传播，这一发现得到了免疫前雪貂体内1组血凝素茎部和N1神经氨酸酶抗体存在情况的支持。我们的研究结果表明，先前感染甲型流感病毒（H1N1）pdm09毒株可能会对甲型流感病毒（H5N1）2.3.4.4b分支毒株提供一定程度的保护。
