Sur Daniel, Coza Ovidiu, Havasi Andrei, Cainap Calin, Burz Claudia, Vlad Catalin, Balacescu Ovidiu, Alexandru Irimie, Lisencu Cosmin
Department of Medical Oncology, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca 400015, Romania.
J BUON. 2020 Jan-Feb;25(1):23-34.
In this review, we focused on presenting an up-to-date overview of exosomal miRNAs as biomarkers for diagnosis, prognosis, and their therapeutically perspectives in colorectal cancer (CRC).
A comprehensive literature search was conducted using the PUBMED database through February 2019 to identify all studies concerning the role of miRNAs and exosomes in CRC.
Among the 77 studies identified, 43 articles were relevant for the collaboration of miRNAs and exosomes as therapeutic and diagnostic opportunities in CRC.
This review reveals the role of exosomal miRNAs in CRC management and discusses the promises and challenges associated with the introduction of this combination into clinical practice.
在本综述中，我们着重介绍外泌体微小RNA（miRNA）作为生物标志物在结直肠癌（CRC）诊断、预后及治疗方面的最新概况。
通过使用PUBMED数据库进行全面的文献检索，检索截至2019年2月的所有关于miRNA和外泌体在CRC中作用的研究。
在检索到的77项研究中，有43篇文章涉及miRNA和外泌体作为CRC治疗和诊断机会的联合应用。
本综述揭示了外泌体miRNA在CRC管理中的作用，并讨论了将这种联合应用引入临床实践所带来的前景和挑战。
