非编码 RNA 调控衰老和老化过程中端粒稳态。
Noncoding RNAs Controlling Telomere Homeostasis in Senescence and Aging.
机构信息
Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA.
Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA.
出版信息
Trends Mol Med. 2020 Apr;26(4):422-433. doi: 10.1016/j.molmed.2020.01.010. Epub 2020 Feb 28.
Abstract
Aging is a universal and time-dependent biological decline associated with progressive deterioration of cells, tissues, and organs. Age-related decay can eventually lead to pathology such as cardiovascular and neurodegenerative diseases, cancer, and diabetes. A prominent molecular process underlying aging is the progressive shortening of telomeres, the structures that protect the ends of chromosomes, eventually triggering cellular senescence. Noncoding (nc)RNAs are emerging as major regulators of telomere length homeostasis. In this review, we describe the impact of ncRNAs on telomere function and discuss their implications in senescence and age-related diseases. We discuss emerging therapeutic strategies targeting telomere-regulatory ncRNAs in aging pathology.
摘要
衰老是一种与细胞、组织和器官进行性恶化相关的普遍的、随时间变化的生物学衰退。与年龄相关的衰退最终可能导致心血管和神经退行性疾病、癌症和糖尿病等病理学疾病。衰老的一个突出的分子过程是端粒的逐渐缩短，端粒是保护染色体末端的结构，最终引发细胞衰老。非编码（nc）RNAs 正在成为端粒长度动态平衡的主要调节剂。在这篇综述中，我们描述了 ncRNAs 对端粒功能的影响，并讨论了它们在衰老和与年龄相关的疾病中的意义。我们讨论了针对衰老病理中端粒调节 ncRNAs 的新兴治疗策略。
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