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天然和热改性麻疯树胶对离子胶乳稳定性的影响。

Impact on stabilization of ionic gum emulsions by natural and thermally modified Chironji gum.

机构信息

Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, Jharkhand, India.

Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, Jharkhand, India.

出版信息

Int J Biol Macromol. 2020 Aug 1;156:233-238. doi: 10.1016/j.ijbiomac.2020.04.042. Epub 2020 Apr 8.

Abstract

Ionic gums like acacia and tragacanth are known for their emulsifying properties but lower viscosity limits its use. This study explores the effects of natural chironji gum and its thermally modified form on the emulsifying properties of acacia and tragacanth. Formulations of chironji gum (CG) O/W emulsion FA1-FA4 were prepared with acacia and FT1-FT4 with tragacanth respectively. Heat treated gums(CGTs) were obtained by heating CG at 110 °C for time intervals 24 h, 48 h and 96 h. Similarly formulations FHA1-FHA12 and FHT1-FHT12 were prepared with acacia and tragacanth replacing CG with heat treated gums. Heat treated gum formulations showed better stabilizing properties than natural CG emulsions. The FA1-FA4 and FT1-FT4 formulations had droplet size in the range of 9.77-26.55 μm and zeta potential ranging from -14.8 mV to -23.2 mV. In contrast, the droplet size and zeta potential of FHA1-FHA12 and FHT1-FHT12 were in range of 1.42-17.5 μm and -17.2 mV to -40.6 mV respectively signifying improved stabilizing capacity of CGT gums. The droplet size and zeta potential of these formulations remained stable even after 7 days of storage at room temperature with no visible phase separation of the formulation observed for more than a month.

摘要

离子胶,如阿拉伯胶和刺槐豆胶,以其乳化性能而闻名,但较低的黏度限制了其应用。本研究探讨了天然乳香胶及其热改性形式对阿拉伯胶和刺槐豆胶乳化性能的影响。乳香胶(CG)O/W 乳液 FA1-FA4 的配方分别用阿拉伯胶和 FT1-FT4 用刺槐豆胶制备。通过将 CG 在 110°C 下加热 24、48 和 96 小时,获得热改性胶(CGTs)。同样,用热改性胶替代 CG,制备了用阿拉伯胶和刺槐豆胶制成的 FHA1-FHA12 和 FHT1-FHT12 配方。热改性胶配方比天然 CG 乳液具有更好的稳定性能。FA1-FA4 和 FT1-FT4 配方的粒径范围为 9.77-26.55μm,ζ 电位范围为-14.8mV 至-23.2mV。相比之下,FHA1-FHA12 和 FHT1-FHT12 的粒径和 ζ 电位分别在 1.42-17.5μm 和-17.2mV 至-40.6mV 范围内,表明 CGT 胶具有更好的稳定能力。即使在室温下储存 7 天,这些配方的粒径和 ζ 电位仍然稳定,在一个月以上的时间内没有观察到配方的可见相分离。

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