Key Laboratory of Modern Acoustics (MOE), Department of Physics, Collaborative Innovation Center of Advanced Microstructure, Nanjing University, Nanjing 210093, China.
Department of Ultrasound in Medicine, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Ultrason Sonochem. 2020 Oct;67:105096. doi: 10.1016/j.ultsonch.2020.105096. Epub 2020 Mar 26.
The past several decades have witnessed great progress in "smart drug delivery", an advance technology that can deliver genes or drugs into specific locations of patients' body with enhanced delivery efficiency. Ultrasound-activated mechanical force induced by the interactions between microbubbles and cells, which can stimulate so-called "sonoporation" process, has been regarded as one of the most promising candidates to realize spatiotemporal-controllable drug delivery to selected regions. Both experimental and numerical studies were performed to get in-depth understanding on how the microbubbles interact with cells during sonoporation processes, under different impact parameters. The current work gives an overview of the general mechanism underlying microbubble-mediated sonoporation, and the possible impact factors (e.g., the properties of cavitation agents and cells, acoustical driving parameters and bubble/cell micro-environment) that could affect sonoporation outcomes. Finally, current progress and considerations of sonoporation in clinical applications are reviewed also.
过去几十年见证了“智能药物输送”的巨大进展，这是一种先进的技术，可以将基因或药物递送到患者体内的特定位置，提高输送效率。超声激活的机械力是由微泡和细胞之间的相互作用引起的，它可以刺激所谓的“声孔”过程，被认为是实现对选定区域进行时空可控药物输送的最有前途的候选者之一。在不同的冲击参数下，进行了实验和数值研究，以深入了解声孔化过程中微泡与细胞的相互作用。目前的工作概述了微泡介导的声孔化的一般机制，以及可能影响声孔化结果的一些因素（例如，空化剂和细胞的特性、声驱动参数和泡/细胞微环境）。最后，还回顾了声孔化在临床应用中的最新进展和考虑因素。
