Izvolskaia Marina, Sharova Viktoriya, Zakharova Liudmila
Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 26 Vavilov Street, Moscow, 119334, Russia.
Inflammation. 2020 Aug;43(4):1175-1183. doi: 10.1007/s10753-020-01220-1.
Viral and bacterial infections causing systemic inflammation are significant risk factors for developing body. Inflammatory processes can alter physiological levels of regulatory factors and interfere with developmental mechanisms. The brain is the main target for the negative impact of inflammatory products during critical ontogenetic periods. Subsequently, the risks of various neuropsychiatric diseases such as Alzheimer's and Parkinson's diseases, schizophrenia, and depression are increased in the offspring. Inflammation-induced physiological disturbances can cause immune and behavioral disorders, reproductive deficiencies, and infertility. The influence of maternal immune stress is mediated by the regulation of pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, monocyte chemotactic protein 1, leukemia-inhibiting factor, and tumor necrosis factor-alpha secretion in the maternal-fetal system. The increasing number of patients with neuronal and reproductive disorders substantiates the identification of biomarkers for these disorders targeted at their therapy.
引起全身炎症的病毒和细菌感染是身体发育的重要危险因素。炎症过程会改变调节因子的生理水平，并干扰发育机制。在关键的个体发育时期，大脑是炎症产物负面影响的主要靶点。随后，后代患各种神经精神疾病如阿尔茨海默病和帕金森病、精神分裂症和抑郁症的风险会增加。炎症引起的生理紊乱可导致免疫和行为障碍、生殖缺陷和不孕。母体免疫应激的影响是通过调节母胎系统中促炎细胞因子如白细胞介素（IL）-1β、IL-6、单核细胞趋化蛋白1、白血病抑制因子和肿瘤坏死因子-α的分泌来介导的。神经元和生殖障碍患者数量的增加证实了针对这些疾病治疗的生物标志物的识别。
